The metabolic clearance rate of dehydroisoandrosterone sulfate. IV. Acute effects of induced hypertension, hypotension, and naturesis in normal and hypertensive pregnancies

N. F. Gant, J. D. Madden, P. K. Siiteri, P. C. MacDonald

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In the present study the metabolic clearance rate of dehydroisoandrosterone sulfate (MCR(DS)) decreased in normotensive gravidas during short term studies utilizing angiotensin II induced elevation of blood pressure. Therapy with hydralazine hydrochloride in chronic hypertensive gravidas resulted in a decrease in blood pressure and an accompanying decrease in the MCR(DS). A variable response was observed in the apparent volume of distribution of DS (AVD(DS)) during therapy with hydralazine hydrochloride. Decreases in MCR(DS) also occurred in chronic hypertensive gravidas following therapy with 40 mg. of intravenously administered furosemide despite a failure of blood pressure to be altered. The AVD(DS) increased in four of five patients receiving furosemide, suggesting a possible direct action of furosemide upon vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume124
Issue number2
StatePublished - 1976

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Controlled Hypotension
Metabolic Clearance Rate
Dehydroepiandrosterone Sulfate
Furosemide
Hypertension
Hydralazine
Pregnancy
Blood Pressure
Vascular Smooth Muscle
Angiotensin II
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

The metabolic clearance rate of dehydroisoandrosterone sulfate. IV. Acute effects of induced hypertension, hypotension, and naturesis in normal and hypertensive pregnancies. / Gant, N. F.; Madden, J. D.; Siiteri, P. K.; MacDonald, P. C.

In: American Journal of Obstetrics and Gynecology, Vol. 124, No. 2, 1976, p. 143-148.

Research output: Contribution to journalArticle

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