The metabolic derangements and treatment of diabetic ketoacidosis

D. W. Foster, J. D. McGarry

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203 Scopus citations


Diabetic ketoacidosis is a common illness among patients with diabetes. The exact prevalence is unknown, but in one community the rate was estimated to be 13.4 episodes per 1000 patient-years in young persons with diabetes. It remains a serious event, with mortality rates as high as 6 to 10 per cent. In children under 10 years of age, diabetic ketoacidosis accounts for 70 per cent of diabetes-related deaths. Death may be due to derangements that are directly attributable to ketoacidosis, to complications associated with the illness itself, or to abnormalities induced by treatment. Because a substantial percentage of deaths is probably preventable if appropriate treatment is delivered, knowledge about the metabolic derangements and treatment of diabetic ketoacidosis is crucial.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalNew England Journal of Medicine
Issue number3
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Medicine(all)

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