The metabolism of phosphoinositide-derived messenger molecules

Philip W. Majerus, Thomas M. Connolly, Hans Deckmyn, Theodora S. Ross, Teresa E. Bross, Hidemi Ishii, Vinay S. Bansal, David B. Wilson

Research output: Contribution to journalArticle

462 Scopus citations

Abstract

The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.

Original languageEnglish (US)
Pages (from-to)1519-1526
Number of pages8
JournalScience
Volume234
Issue number4783
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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    Majerus, P. W., Connolly, T. M., Deckmyn, H., Ross, T. S., Bross, T. E., Ishii, H., Bansal, V. S., & Wilson, D. B. (1986). The metabolism of phosphoinositide-derived messenger molecules. Science, 234(4783), 1519-1526. https://doi.org/10.1126/science.3024320