The metabolism of phosphoinositide-derived messenger molecules

Philip W. Majerus, Thomas M. Connolly, Hans Deckmyn, Theodora S. Ross, Teresa E. Bross, Hidemi Ishii, Vinay S. Bansal, David B. Wilson

Research output: Contribution to journalArticle

462 Citations (Scopus)

Abstract

The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.

Original languageEnglish (US)
Pages (from-to)1519-1526
Number of pages8
JournalScience
Volume234
Issue number4783
StatePublished - 1986

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Phosphatidylinositols
Eukaryotic Cells
Phospholipids
Cell Membrane

ASJC Scopus subject areas

  • General

Cite this

Majerus, P. W., Connolly, T. M., Deckmyn, H., Ross, T. S., Bross, T. E., Ishii, H., ... Wilson, D. B. (1986). The metabolism of phosphoinositide-derived messenger molecules. Science, 234(4783), 1519-1526.

The metabolism of phosphoinositide-derived messenger molecules. / Majerus, Philip W.; Connolly, Thomas M.; Deckmyn, Hans; Ross, Theodora S.; Bross, Teresa E.; Ishii, Hidemi; Bansal, Vinay S.; Wilson, David B.

In: Science, Vol. 234, No. 4783, 1986, p. 1519-1526.

Research output: Contribution to journalArticle

Majerus, PW, Connolly, TM, Deckmyn, H, Ross, TS, Bross, TE, Ishii, H, Bansal, VS & Wilson, DB 1986, 'The metabolism of phosphoinositide-derived messenger molecules', Science, vol. 234, no. 4783, pp. 1519-1526.
Majerus PW, Connolly TM, Deckmyn H, Ross TS, Bross TE, Ishii H et al. The metabolism of phosphoinositide-derived messenger molecules. Science. 1986;234(4783):1519-1526.
Majerus, Philip W. ; Connolly, Thomas M. ; Deckmyn, Hans ; Ross, Theodora S. ; Bross, Teresa E. ; Ishii, Hidemi ; Bansal, Vinay S. ; Wilson, David B. / The metabolism of phosphoinositide-derived messenger molecules. In: Science. 1986 ; Vol. 234, No. 4783. pp. 1519-1526.
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