The Meter of Metabolism

Research output: Contribution to journalReview article

607 Scopus citations

Abstract

The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.

Original languageEnglish (US)
Pages (from-to)728-742
Number of pages15
JournalCell
Volume134
Issue number5
DOIs
StatePublished - Sep 5 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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