TY - JOUR
T1 - The Meter of Metabolism
AU - Green, Carla B.
AU - Takahashi, Joseph S.
AU - Bass, Joseph
N1 - Funding Information:
We thank K.M. Ramsey and B. Marcheva for assistance with figures. This work was supported by National Institutes of Health grants R01 GM076626 and P50 MH074924 Project 4 to C.B.G., R01 MH078024 and P50 MH074924 (Director, Silvio O. Conte Center) to J.S.T., and P01 AG011412 Project 6 and R01 HL075029 to J.B. J.S.T. is an Investigator of the Howard Hughes Medical Institute. J.S.T is a cofounder of ReSet Therapeutics Inc. and C.B.G., J.S.T., and J.B. are members of its scientific advisory board. J.B. has also been an advisor and received research support from Amylin Pharmaceuticals and from the Juvenile Diabetes Research Foundation International.
PY - 2008/9/5
Y1 - 2008/9/5
N2 - The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.
AB - The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a complex feedback network that involves interactions between the central nervous system and peripheral tissues. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also feed back into the circadian system, modulating circadian gene expression and behavior. Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes.
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U2 - 10.1016/j.cell.2008.08.022
DO - 10.1016/j.cell.2008.08.022
M3 - Review article
C2 - 18775307
AN - SCOPUS:50249100374
SN - 0092-8674
VL - 134
SP - 728
EP - 742
JO - Cell
JF - Cell
IS - 5
ER -