The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Gγ1

Pang Yi, Zhe Han, Xiumin Li, Eric H. Olson

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The early morphogenetic mechanisms involved in heart formation are evolutionarily conserved. A screen for genes that control Drosophila heart development revealed a cardiac defect in which pericardial and cardial cells dissociate, which causes loss of cardiac function and embryonic lethality. This phenotype resulted from mutations in the genes encoding HMG-CoA reductase, downstream enzymes in the mevalonate pathway, and G protein Gγ1, which is geranylgeranylated, thus representing an end point of isoprenoid biosynthesis. Our findings reveal a cardial cell-autonomous requirement of Gγ1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in congenital heart disease.

Original languageEnglish (US)
Pages (from-to)1301-1303
Number of pages3
JournalScience
Volume313
Issue number5791
DOIs
StatePublished - Sep 1 2006

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Prenylation
Mevalonic Acid
Drosophila
Hydroxymethylglutaryl CoA Reductases
Terpenes
GTP-Binding Proteins
Genes
Heart Diseases
Phenotype
Mutation
Enzymes

ASJC Scopus subject areas

  • General

Cite this

The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Gγ1. / Yi, Pang; Han, Zhe; Li, Xiumin; Olson, Eric H.

In: Science, Vol. 313, No. 5791, 01.09.2006, p. 1301-1303.

Research output: Contribution to journalArticle

Yi, Pang ; Han, Zhe ; Li, Xiumin ; Olson, Eric H. / The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Gγ1. In: Science. 2006 ; Vol. 313, No. 5791. pp. 1301-1303.
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