The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Gγ1

Pang Yi, Zhe Han, Xiumin Li, Eric H. Olson

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The early morphogenetic mechanisms involved in heart formation are evolutionarily conserved. A screen for genes that control Drosophila heart development revealed a cardiac defect in which pericardial and cardial cells dissociate, which causes loss of cardiac function and embryonic lethality. This phenotype resulted from mutations in the genes encoding HMG-CoA reductase, downstream enzymes in the mevalonate pathway, and G protein Gγ1, which is geranylgeranylated, thus representing an end point of isoprenoid biosynthesis. Our findings reveal a cardial cell-autonomous requirement of Gγ1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in congenital heart disease.

Original languageEnglish (US)
Pages (from-to)1301-1303
Number of pages3
JournalScience
Volume313
Issue number5791
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Gγ1'. Together they form a unique fingerprint.

  • Cite this