The MFMU Cesarean Registry: Uterine atony after primary cesarean delivery

Dwight J. Rouse, Sharon Leindecker, Mark Landon, Steven L. Bloom, Michael W. Varner, Atef H. Moawad, Catherine Y. Spong, Steve N. Caritis, Margaret Harper, Ronald J. Wapner, Yoram Sorokin, Menachem Miodovnik, Mary Jo O'Sullivan, Baha M. Sibai, Oded Langer

Research output: Contribution to journalArticle

42 Scopus citations


Objective: The purpose of this study was to define independent risk factors for uterine atony after primary cesarean delivery, and to assess their overall association with atony in the study cohort. Study design: This was a 13-university center prospective observational study. All women who underwent primary cesarean from January 1, 1999 to December 31, 2000 were eligible. Trained and certified research nurses performed systematic data abstraction. The definition of atony required both the clinical diagnosis and the use of methergine or a prostaglandin preparation. Risk factors for uterine atony were assessed in univariable and multivariable logistic regression analyses, and these analyses then used to inform an assessment of the association of the various risk factors with the occurrence of uterine atony in the overall cohort. Results: Twenty-three thousand, three hundred and ninety pregnancies were analyzed. Uterine atony occurred in 1416 women (6%). Several variables were independently associated with atony in a multivariable model, including multiple gestation (odds ratio [OR] 2.40, 95% CI 1.95-2.93), maternal Hispanic race (2.21, 1.90-2.57), induced or augmented labor for >18 hours (2.23, 1.92-2.60), infant birth weight >4500 g (2.05, 1.53-2.69), and clinically diagnosed chorioamnionitis (1.80, 1.55-2.09). However, because the various risk factors were not very powerful, approximately half of the cases of atony were associated with the 2/3 of women lacking a given risk factor or combination of risk factors. Conclusion: Although certain risk factors and uterine atony were clearly associated, the associations are of limited practical clinical use.

Original languageEnglish (US)
Pages (from-to)1056-1060
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Issue number3 SUPPL.
StatePublished - Sep 1 2005



  • Cesarean delivery
  • Uterine atony

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Rouse, D. J., Leindecker, S., Landon, M., Bloom, S. L., Varner, M. W., Moawad, A. H., Spong, C. Y., Caritis, S. N., Harper, M., Wapner, R. J., Sorokin, Y., Miodovnik, M., O'Sullivan, M. J., Sibai, B. M., & Langer, O. (2005). The MFMU Cesarean Registry: Uterine atony after primary cesarean delivery. American journal of obstetrics and gynecology, 193(3 SUPPL.), 1056-1060.