TY - JOUR
T1 - The microbiota regulates type 2 immunity through RORγt+ T cells
AU - Ohnmacht, Caspar
AU - Park, Joo Hong
AU - Cording, Sascha
AU - Wing, James B.
AU - Atarashi, Koji
AU - Obata, Yuuki
AU - Gaboriau-Routhiau, Valérie
AU - Marques, Rute
AU - Dulauroy, Sophie
AU - Fedoseeva, Maria
AU - Busslinger, Meinrad
AU - Cerf-Bensussan, Nadine
AU - Boneca, Ivo G.
AU - Voehringer, David
AU - Hase, Koji
AU - Honda, Kenya
AU - Sakaguchi, Shimon
AU - Eberl, Gérard
PY - 2015/8/28
Y1 - 2015/8/28
N2 - Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (TH17) cells and regulatory T cells (Tregs) in the intestine. Here, we report that microbiota-induced Tregs express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to TH17 cells. In the absence of RORγt+ Tregs, TH2-driven defense against helminths is more efficient, whereas TH2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 RORγt+ Tregs and TH17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.
AB - Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (TH17) cells and regulatory T cells (Tregs) in the intestine. Here, we report that microbiota-induced Tregs express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to TH17 cells. In the absence of RORγt+ Tregs, TH2-driven defense against helminths is more efficient, whereas TH2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 RORγt+ Tregs and TH17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.
UR - http://www.scopus.com/inward/record.url?scp=84940547063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940547063&partnerID=8YFLogxK
U2 - 10.1126/science.aac4263
DO - 10.1126/science.aac4263
M3 - Article
C2 - 26160380
AN - SCOPUS:84940547063
SN - 0036-8075
VL - 349
SP - 989
EP - 993
JO - Science
JF - Science
IS - 6251
ER -