The MIs locus: new clues to a lingering mystery

The MIs locus was described in the late 1960s by Hilliard Festenstein; cultures of lymphocytes with a disparity at this locus induces intense, unidirectional T-cell proliferative responses. The genetics and immunobiology of this immunological enigma were discussed at a recent Howard Hughes Medical Institute Workshop.^* * Held at the Howard Hughes Medical Institute Conference Center, Coconut Grove, Florida, USA on 1-4 November 1987.