The mitogen-activated protein kinases, ERK1 and ERK2

Melanie H. Cobb; Jessie E. Hepler; Mangeng Cheng; David Robbins

The mitogen-activated protein kinases, ERK1 and ERK2

Melanie H. Cobb, Jessie E. Hepler, Mangeng Cheng, David Robbins

Research output: Contribution to journal › Article › peer-review

Abstract

The MAP kinases are ubiquitous enzymes that are activated in a complex fashion and inactivated by multiple phosphatases including a dedicated dual specificity enzyme. These kinases have a diverse array of substrates with important functions that result in their substantial regulatory impact. The ERK/MAP kinase cascade displays not only downstream but also upstream interactions as well as cross talk with other signaling pathways which fine tunes the cascade in a cell type-specific fashion. Transforming agents utilize this cascade in inducing cell proliferation.

Original language	English (US)
Pages (from-to)	261-268
Number of pages	8
Journal	Seminars in Cancer Biology
Volume	5
Issue number	4
State	Published - 1994

Keywords

Extracellular signal-regulated kinase
MAP kinase

ASJC Scopus subject areas

Cancer Research

Cite this

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AU - Cheng, Mangeng

AU - Robbins, David

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AB - The MAP kinases are ubiquitous enzymes that are activated in a complex fashion and inactivated by multiple phosphatases including a dedicated dual specificity enzyme. These kinases have a diverse array of substrates with important functions that result in their substantial regulatory impact. The ERK/MAP kinase cascade displays not only downstream but also upstream interactions as well as cross talk with other signaling pathways which fine tunes the cascade in a cell type-specific fashion. Transforming agents utilize this cascade in inducing cell proliferation.

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The mitogen-activated protein kinases, ERK1 and ERK2

Abstract

Keywords

ASJC Scopus subject areas

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