The molecular basis of colon cancer

Anil K. Rustgi, Daniel K. Podolsky

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

There are approximately 160,000 new cases of colon cancer every year in the United States. Colon carcinoma results from the aggregate effects of multiple genetic alterations. Some genetic alterations may be inherited, while others reflect somatic mutations. The latter may themselves be the indirect result of environmental factors such as diet. It is the total accumulation of these genetic changes, combining the activation of oncogenes with the inactivation of tumor suppressor genes, that is responsible for determining the biologic properties of colon cancer.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalAnnual Review of Medicine
Volume43
StatePublished - 1992

Fingerprint

Nutrition
Colonic Neoplasms
Tumors
Genes
Chemical activation
Tumor Suppressor Genes
Oncogenes
Colon
Diet
Carcinoma
Mutation

Keywords

  • chromosomal allelic deletion
  • dominant oncogene
  • hereditary polyposis syndromes
  • tumor suppressor gene

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

The molecular basis of colon cancer. / Rustgi, Anil K.; Podolsky, Daniel K.

In: Annual Review of Medicine, Vol. 43, 1992, p. 61-68.

Research output: Contribution to journalArticle

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