The molecular biology of hair cell regeneration in the avian cochlea

Ann E. Riedl, Kenneth H. Lee, Loralyn A. Moskalyk, Douglas A. Cotanche

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The sensory cells of the ear, the hair cells, are damaged by loud noise or certain types of drugs. In the bird cochlea, new hair cells are produced to replace those that are lost. Regeneration also occurs in the vestibular epithelia of birds, fish, and mammals but does not occur in the mammalian cochlea. In order to further our understanding of the regeneration process in the bird cochlea, we have begun to identify the genes that are involved. However, the small size of this organ has made it difficult to use traditional molecular biology methods to address these problems. Recently, many molecular techniques have been adapted for use with small amounts of tissue. Northern blot analysis, the ribonuclease protection assay, semiquantitative PCR and differential display of mRNA are all techniques that are being used to greatly improve our understanding of hair cell regeneration and may eventually provide the information necessary to induce regeneration in hearing-impaired humans.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalAudiology and Neuro-Otology
Volume2
Issue number1-2
StatePublished - Jan 1997

Fingerprint

Cochlea
Regeneration
Molecular Biology
Birds
Organ Size
Gene Expression Profiling
Ribonucleases
Northern Blotting
Hearing
Ear
Noise
Mammals
Fishes
Epithelium
Polymerase Chain Reaction
Pharmaceutical Preparations
Genes

Keywords

  • Cochlea
  • Differential display
  • Hair cell
  • Molecular biology
  • Northern blot
  • PCR
  • Regeneration
  • Ribonuclease protection assay
  • RNA isolation

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Neuroscience(all)
  • Physiology

Cite this

Riedl, A. E., Lee, K. H., Moskalyk, L. A., & Cotanche, D. A. (1997). The molecular biology of hair cell regeneration in the avian cochlea. Audiology and Neuro-Otology, 2(1-2), 61-70.

The molecular biology of hair cell regeneration in the avian cochlea. / Riedl, Ann E.; Lee, Kenneth H.; Moskalyk, Loralyn A.; Cotanche, Douglas A.

In: Audiology and Neuro-Otology, Vol. 2, No. 1-2, 01.1997, p. 61-70.

Research output: Contribution to journalArticle

Riedl, AE, Lee, KH, Moskalyk, LA & Cotanche, DA 1997, 'The molecular biology of hair cell regeneration in the avian cochlea', Audiology and Neuro-Otology, vol. 2, no. 1-2, pp. 61-70.
Riedl, Ann E. ; Lee, Kenneth H. ; Moskalyk, Loralyn A. ; Cotanche, Douglas A. / The molecular biology of hair cell regeneration in the avian cochlea. In: Audiology and Neuro-Otology. 1997 ; Vol. 2, No. 1-2. pp. 61-70.
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