The molecular biology of nucleotide excision repair of DNA: recent progress.

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Abstract

Recent years have witnessed significant progress towards understanding the molecular mechanism of nucleotide excision repair in living cells. Biochemical studies in Escherichia coli, and genetic and molecular studies in lower and higher eukaryotes have revealed an unexpected complexity suggesting interesting protein-protein and protein-DNA interactions. This review considers selected aspects of nucleotide excision repair in E. coli, Saccharomyces cerevisiae and mammalian cells, with a particular emphasis on new observations and on models that may provide explanations for the complexity evident from genetic and biochemical studies.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalJournal of cell science. Supplement
Volume6
StatePublished - 1987

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DNA Repair
Molecular Biology
DNA
Escherichia coli
Proteins
Eukaryota
Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Medicine(all)
  • Cell Biology

Cite this

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title = "The molecular biology of nucleotide excision repair of DNA: recent progress.",
abstract = "Recent years have witnessed significant progress towards understanding the molecular mechanism of nucleotide excision repair in living cells. Biochemical studies in Escherichia coli, and genetic and molecular studies in lower and higher eukaryotes have revealed an unexpected complexity suggesting interesting protein-protein and protein-DNA interactions. This review considers selected aspects of nucleotide excision repair in E. coli, Saccharomyces cerevisiae and mammalian cells, with a particular emphasis on new observations and on models that may provide explanations for the complexity evident from genetic and biochemical studies.",
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