The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics

Julie K. Iwasaki, Divya Srivastava, Ronald L. Moy, Henry J. Lin, David J. Kouba

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Mutations in the sonic hedgehog signaling pathway play a key role in the development of basal cell carcinomas. Specifically, mutations in the PTCH1 (also known as PTCH or PTC1) and SMO genes cause tumor formation through constitutive activation of the pathway. Misregulation of the pathway has also been implicated in the nevoid basal cell carcinoma syndrome and other tumors. Understanding the function of the sonic hedgehog pathway has led to novel strategies for treatment. In this review we highlight the role of the pathway in the pathogenesis of basal cell carcinoma and review potential targeted therapies.

Original languageEnglish (US)
Pages (from-to)e167-e178
JournalJournal of the American Academy of Dermatology
Volume66
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • basal cell
  • carcinoma
  • sonic hedgehog

ASJC Scopus subject areas

  • Dermatology

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