The molecular machinery of regulated cell death

Daolin Tang, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, Guido Kroemer

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.

Original languageEnglish (US)
Pages (from-to)347-364
Number of pages18
JournalCell Research
Volume29
Issue number5
DOIs
StatePublished - May 1 2019

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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