The natural history of lung function after lung transplantation for α1-antitrypsin deficiency

Amit Banga, Thomas Gildea, Jeevanantham Rajeswaran, Haala Rokadia, Eugene H. Blackstone, James K. Stoller

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Rationale: Lung transplantation (LT) is an established treatment for end-stage lung diseases, including chronic obstructive pulmonary disease (COPD) associated with α1-antitrypsin deficiency (AATD). Objectives: We sought to compare the post-transplantation course of patients with AATD and AAT-replete COPD. Methods: Between June 1991 and January 2008, a total of 231 patients with AAT-replete COPD and 45 with AATD underwent LT at Cleveland Clinic. Data reviewed included baseline recipient, donor, and surgical data; all spirometry evaluations; acute cellular rejection (ACR) events; and survival data. Endpoints included temporal change in FEV1, severity of ACR, and survival. A longitudinal temporal decomposition model was used for analysis. Measurements and Main Results: Comparison of overall rates of FEV1 decline in AATD and AAT-replete patients with COPD showed no significant differences (P > 0.09). However, although the single LT patients had similar trends in FEV1 in both groups, patients with AATD with double LT declined faster (P < 0.002) than the AAT-replete patients. No differences in the frequency or severity of ACR episodes were observed (P = 0.32). Furthermore, there was no difference in early or late mortality between patients with AATD and patients with AAT-replete COPD (P > 0.09). Conclusions: Although overall the post-LT FEV1 slope, severity of ACR, and survival among patients with AATD is similar to that of AAT-replete patients with COPD, patients with AATD with double LT have a faster rate of FEV1 decline. These findings support the eligibility of patients with AATD for LT, and suggest the need for additional studies to better understand the difference between single and double LT in AATD.

Original languageEnglish (US)
Pages (from-to)274-281
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Volume190
Issue number3
DOIs
StatePublished - Aug 1 2014

Keywords

  • FEV<inf>1</inf> slope
  • Lung transplantation
  • Mixed modeling
  • α1-antitrypsin deficiency

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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