The natural history of petroclival meningiomas: A volumetric study

Jacob B. Hunter, Robert J. Yawn, Ray Wang, Brendan P. O'Connell, Matthew L. Carlson, Akshitkumar Mistry, David S. Haynes, Reid C. Thompson, Kyle D. Weaver, George B. Wanna

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: This study characterizes primary petroclival meningioma growth rates, before intervention, using volumetric analysis. In addition, predictors of growth are analyzed. Methods: Patients with previously untreated petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was used to perform volumetric analyses of tumor size and growth. Three-dimensional segmentation volumetric analyses were compared with volumes estimated utilizing three orthogonal dimensions. Tumor growth was defined as a 15% increase in volume. Results: Thirty-four patients who underwent at least two magnetic resonance imaging (MRI) studies before intervention were included. The mean age was 55.2 years, and 65.7% were women. The mean tumor volume at presentation was 5.6 cm3 (range, 0.1-25.8 cm3) as determined from segmentation volumetric analysis. At a mean follow-up of 44.5 months (range, 3.7-125.1 mo), 88.2% of tumors grew. The mean annual volumetric growth rate was 2.38 cm3/yr (-0.63 to 25.9 cm3/yr). Tumor volume, T2 hyperintensity within the tumor, peritumoral edema, and ataxia and/or cerebellar symptoms at presentation were all significantly associated with greater rates of tumor growth. Ultimately, 10 (29.4%) patients underwent treatment during the follow-up period. Conclusion: Our experience demonstrates that the vast majority (88%) of untreated petroclival meningiomas grow; the mean volumetric growth rate was noted to be 2.38 cm3/ yr. We found a significant association between increased growth rate and larger tumor size at diagnosis, T2 hyperintensity within the tumor, peritumoral edema, and the presence of ataxia and/or cerebellar symptoms.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalOtology and Neurotology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Meningioma
Natural History
Growth
Neoplasms
Cerebellar Ataxia
Tumor Burden
Edema
Software
Magnetic Resonance Imaging

Keywords

  • Meningioma
  • Natural history
  • Petroclival meningioma
  • Skull base
  • Volumetric growth

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

Cite this

Hunter, J. B., Yawn, R. J., Wang, R., O'Connell, B. P., Carlson, M. L., Mistry, A., ... Wanna, G. B. (2017). The natural history of petroclival meningiomas: A volumetric study. Otology and Neurotology, 38(1), 123-128. https://doi.org/10.1097/MAO.0000000000001260

The natural history of petroclival meningiomas : A volumetric study. / Hunter, Jacob B.; Yawn, Robert J.; Wang, Ray; O'Connell, Brendan P.; Carlson, Matthew L.; Mistry, Akshitkumar; Haynes, David S.; Thompson, Reid C.; Weaver, Kyle D.; Wanna, George B.

In: Otology and Neurotology, Vol. 38, No. 1, 01.01.2017, p. 123-128.

Research output: Contribution to journalArticle

Hunter, JB, Yawn, RJ, Wang, R, O'Connell, BP, Carlson, ML, Mistry, A, Haynes, DS, Thompson, RC, Weaver, KD & Wanna, GB 2017, 'The natural history of petroclival meningiomas: A volumetric study', Otology and Neurotology, vol. 38, no. 1, pp. 123-128. https://doi.org/10.1097/MAO.0000000000001260
Hunter, Jacob B. ; Yawn, Robert J. ; Wang, Ray ; O'Connell, Brendan P. ; Carlson, Matthew L. ; Mistry, Akshitkumar ; Haynes, David S. ; Thompson, Reid C. ; Weaver, Kyle D. ; Wanna, George B. / The natural history of petroclival meningiomas : A volumetric study. In: Otology and Neurotology. 2017 ; Vol. 38, No. 1. pp. 123-128.
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abstract = "Objectives: This study characterizes primary petroclival meningioma growth rates, before intervention, using volumetric analysis. In addition, predictors of growth are analyzed. Methods: Patients with previously untreated petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was used to perform volumetric analyses of tumor size and growth. Three-dimensional segmentation volumetric analyses were compared with volumes estimated utilizing three orthogonal dimensions. Tumor growth was defined as a 15{\%} increase in volume. Results: Thirty-four patients who underwent at least two magnetic resonance imaging (MRI) studies before intervention were included. The mean age was 55.2 years, and 65.7{\%} were women. The mean tumor volume at presentation was 5.6 cm3 (range, 0.1-25.8 cm3) as determined from segmentation volumetric analysis. At a mean follow-up of 44.5 months (range, 3.7-125.1 mo), 88.2{\%} of tumors grew. The mean annual volumetric growth rate was 2.38 cm3/yr (-0.63 to 25.9 cm3/yr). Tumor volume, T2 hyperintensity within the tumor, peritumoral edema, and ataxia and/or cerebellar symptoms at presentation were all significantly associated with greater rates of tumor growth. Ultimately, 10 (29.4{\%}) patients underwent treatment during the follow-up period. Conclusion: Our experience demonstrates that the vast majority (88{\%}) of untreated petroclival meningiomas grow; the mean volumetric growth rate was noted to be 2.38 cm3/ yr. We found a significant association between increased growth rate and larger tumor size at diagnosis, T2 hyperintensity within the tumor, peritumoral edema, and the presence of ataxia and/or cerebellar symptoms.",
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AU - Carlson, Matthew L.

AU - Mistry, Akshitkumar

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AB - Objectives: This study characterizes primary petroclival meningioma growth rates, before intervention, using volumetric analysis. In addition, predictors of growth are analyzed. Methods: Patients with previously untreated petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was used to perform volumetric analyses of tumor size and growth. Three-dimensional segmentation volumetric analyses were compared with volumes estimated utilizing three orthogonal dimensions. Tumor growth was defined as a 15% increase in volume. Results: Thirty-four patients who underwent at least two magnetic resonance imaging (MRI) studies before intervention were included. The mean age was 55.2 years, and 65.7% were women. The mean tumor volume at presentation was 5.6 cm3 (range, 0.1-25.8 cm3) as determined from segmentation volumetric analysis. At a mean follow-up of 44.5 months (range, 3.7-125.1 mo), 88.2% of tumors grew. The mean annual volumetric growth rate was 2.38 cm3/yr (-0.63 to 25.9 cm3/yr). Tumor volume, T2 hyperintensity within the tumor, peritumoral edema, and ataxia and/or cerebellar symptoms at presentation were all significantly associated with greater rates of tumor growth. Ultimately, 10 (29.4%) patients underwent treatment during the follow-up period. Conclusion: Our experience demonstrates that the vast majority (88%) of untreated petroclival meningiomas grow; the mean volumetric growth rate was noted to be 2.38 cm3/ yr. We found a significant association between increased growth rate and larger tumor size at diagnosis, T2 hyperintensity within the tumor, peritumoral edema, and the presence of ataxia and/or cerebellar symptoms.

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