The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

Dan Soppet, Enrique Escandon, Johnne Maragos, David S. Middlemas, Susan W. Raid, Janet Blair, Louis E. Burton, Brian R. Stanton, David R. Kaplan, Tony Hunter, Karoly Nikolics, Luis F. Parade

Research output: Contribution to journalArticlepeer-review

614 Scopus citations

Abstract

Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk protooncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kinase receptor is rapidly phosphorylated on tyrosine residues upon exposure to the NGF-related neurotrophic factors BDNF and NT-3. Furthermore, gp145rkB specifically binds BDNF and NT-3 in NIH 3T3 cells and in hippocampal cells, but does not bind NGF. Thus, the trk family of receptors are likely to be important signal transducers of NGF-related trophic signals in the formation and maintenance of neuronal circuits.

Original languageEnglish (US)
Pages (from-to)895-903
Number of pages9
JournalCell
Volume65
Issue number5
DOIs
StatePublished - May 31 1991

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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