@article{df9176a82f13495993386b474e3ef695,
title = "The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor",
abstract = "Neurotrophic factors are essential for neuronal survival and function. Recent data have demonstrated that the product of the tyrosine kinase trk protooncogene binds NGF and is a component of the high affinity NGF receptor. Analysis of the trkB gene product, gp145trkB, in NIH 3T3 cells indicates that this tyrosine kinase receptor is rapidly phosphorylated on tyrosine residues upon exposure to the NGF-related neurotrophic factors BDNF and NT-3. Furthermore, gp145rkB specifically binds BDNF and NT-3 in NIH 3T3 cells and in hippocampal cells, but does not bind NGF. Thus, the trk family of receptors are likely to be important signal transducers of NGF-related trophic signals in the formation and maintenance of neuronal circuits.",
author = "Dan Soppet and Enrique Escandon and Johnne Maragos and Middlemas, {David S.} and Raid, {Susan W.} and Janet Blair and Burton, {Louis E.} and Stanton, {Brian R.} and Kaplan, {David R.} and Tony Hunter and Karoly Nikolics and Parade, {Luis F.}",
note = "Funding Information: We would like to thank Drs. M. V. Chao, C. Brannan, J. Winslow, and A. Rosenthal for critical reading of this manuscript and helpful discussions. We thank Drs. T. Jessel, M. Tessier-Lavigne. and A. Davies for providing reagents and M. Gurney for advice in the early stages of this work. We thank Dr. Terry Copeland and Pat Wesdockof the Protein Structure Working Group and Dr. Deborah Morrison for providing pep tides and antibodies. We also thank Richard Frederickson for the prep aration of the fttures and Linda Brubaker and Robin Handley for help in the preparation of the manuscript. This research was supported in part by the National Cancer Institute. DHHS, under contract NOICG-74101 with ABL. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “adverfisement” in accordance with 18 USC Section 1734 solely to indicate this fact.",
year = "1991",
month = may,
day = "31",
doi = "10.1016/0092-8674(91)90396-G",
language = "English (US)",
volume = "65",
pages = "895--903",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}