The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-Fluoropenciclovir)

Hancheng Cai, Duanzhi Yin, Lan Zhang, Yongxian Wang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.

Original languageEnglish (US)
Pages (from-to)837-841
Number of pages5
JournalJournal of Fluorine Chemistry
Volume127
Issue number7
DOIs
StatePublished - Jul 1 2006

Keywords

  • Anti-viral agent
  • Fluorination reaction
  • PET
  • Penciclovir
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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