Abstract
9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.
Original language | English (US) |
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Pages (from-to) | 837-841 |
Number of pages | 5 |
Journal | Journal of Fluorine Chemistry |
Volume | 127 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2006 |
Keywords
- Anti-viral agent
- Fluorination reaction
- PET
- Penciclovir
- Synthesis
ASJC Scopus subject areas
- Biochemistry
- Environmental Chemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry