The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-Fluoropenciclovir)

Hancheng Cai, Duanzhi Yin, Lan Zhang, Yongxian Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.

Original languageEnglish (US)
Pages (from-to)837-841
Number of pages5
JournalJournal of Fluorine Chemistry
Volume127
Issue number7
DOIs
StatePublished - Jul 2006

Fingerprint

purines
guanines
nuclear magnetic resonance
Nuclear magnetic resonance
analogs
Guanine
viruses
synthesis
Viruses
inhibitors
inhibitor
virus
products
9-(4-fluoro-3-hydroxymethylbutyl)guanine
2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl)purine
penciclovir
purine
family
product
Proton Magnetic Resonance Spectroscopy

Keywords

  • Anti-viral agent
  • Fluorination reaction
  • Penciclovir
  • PET
  • Synthesis

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

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title = "The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-Fluoropenciclovir)",
abstract = "9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.",
keywords = "Anti-viral agent, Fluorination reaction, Penciclovir, PET, Synthesis",
author = "Hancheng Cai and Duanzhi Yin and Lan Zhang and Yongxian Wang",
year = "2006",
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TY - JOUR

T1 - The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-Fluoropenciclovir)

AU - Cai, Hancheng

AU - Yin, Duanzhi

AU - Zhang, Lan

AU - Wang, Yongxian

PY - 2006/7

Y1 - 2006/7

N2 - 9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.

AB - 9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.

KW - Anti-viral agent

KW - Fluorination reaction

KW - Penciclovir

KW - PET

KW - Synthesis

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