The new generation of targeted therapies for breast cancer

Samira Syed, Eric Rowinsky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Traditional therapies for breast cancer have generally relied upon the targeting of rapidly proliferating cells by inhibiting DNA replication or cell division. Although this strategy has been effective, its innate lack of selectivity for tumor cells has resulted in diminishing returns, approaching the limits of acceptable toxicity. A growing understanding of the molecular events that mediate tumor growth and metastases has led to the development of rationally designed targeted therapeutics that offer the dual hope of maximizing efficacy and minimizing toxicity to normal tissue. Promising strategies include the inhibition of growth factor receptor and signal transduction pathways, prevention of tumor angiogenesis, modulation of apoptosis, and inhibition of histone deacetylation. This article reviews the development of several novel targeted therapies that may be efficacious in the treatment of patients with breast cancer and highlights the challenges and opportunities associated with these agents.

Original languageEnglish (US)
Pages (from-to)1339-1351
Number of pages13
JournalOncology
Volume17
Issue number10
StatePublished - Oct 2003

Fingerprint

Breast Neoplasms
Neoplasms
Growth Factor Receptors
Therapeutics
DNA Replication
Cell Division
Histones
Signal Transduction
Apoptosis
Neoplasm Metastasis
Growth

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The new generation of targeted therapies for breast cancer. / Syed, Samira; Rowinsky, Eric.

In: Oncology, Vol. 17, No. 10, 10.2003, p. 1339-1351.

Research output: Contribution to journalArticle

Syed, S & Rowinsky, E 2003, 'The new generation of targeted therapies for breast cancer', Oncology, vol. 17, no. 10, pp. 1339-1351.
Syed, Samira ; Rowinsky, Eric. / The new generation of targeted therapies for breast cancer. In: Oncology. 2003 ; Vol. 17, No. 10. pp. 1339-1351.
@article{6019a5664a9249ad85ac3b5daf9fc5c5,
title = "The new generation of targeted therapies for breast cancer",
abstract = "Traditional therapies for breast cancer have generally relied upon the targeting of rapidly proliferating cells by inhibiting DNA replication or cell division. Although this strategy has been effective, its innate lack of selectivity for tumor cells has resulted in diminishing returns, approaching the limits of acceptable toxicity. A growing understanding of the molecular events that mediate tumor growth and metastases has led to the development of rationally designed targeted therapeutics that offer the dual hope of maximizing efficacy and minimizing toxicity to normal tissue. Promising strategies include the inhibition of growth factor receptor and signal transduction pathways, prevention of tumor angiogenesis, modulation of apoptosis, and inhibition of histone deacetylation. This article reviews the development of several novel targeted therapies that may be efficacious in the treatment of patients with breast cancer and highlights the challenges and opportunities associated with these agents.",
author = "Samira Syed and Eric Rowinsky",
year = "2003",
month = "10",
language = "English (US)",
volume = "17",
pages = "1339--1351",
journal = "Oncology",
issn = "0890-9091",
publisher = "UBM Medica Healthcare Publications",
number = "10",

}

TY - JOUR

T1 - The new generation of targeted therapies for breast cancer

AU - Syed, Samira

AU - Rowinsky, Eric

PY - 2003/10

Y1 - 2003/10

N2 - Traditional therapies for breast cancer have generally relied upon the targeting of rapidly proliferating cells by inhibiting DNA replication or cell division. Although this strategy has been effective, its innate lack of selectivity for tumor cells has resulted in diminishing returns, approaching the limits of acceptable toxicity. A growing understanding of the molecular events that mediate tumor growth and metastases has led to the development of rationally designed targeted therapeutics that offer the dual hope of maximizing efficacy and minimizing toxicity to normal tissue. Promising strategies include the inhibition of growth factor receptor and signal transduction pathways, prevention of tumor angiogenesis, modulation of apoptosis, and inhibition of histone deacetylation. This article reviews the development of several novel targeted therapies that may be efficacious in the treatment of patients with breast cancer and highlights the challenges and opportunities associated with these agents.

AB - Traditional therapies for breast cancer have generally relied upon the targeting of rapidly proliferating cells by inhibiting DNA replication or cell division. Although this strategy has been effective, its innate lack of selectivity for tumor cells has resulted in diminishing returns, approaching the limits of acceptable toxicity. A growing understanding of the molecular events that mediate tumor growth and metastases has led to the development of rationally designed targeted therapeutics that offer the dual hope of maximizing efficacy and minimizing toxicity to normal tissue. Promising strategies include the inhibition of growth factor receptor and signal transduction pathways, prevention of tumor angiogenesis, modulation of apoptosis, and inhibition of histone deacetylation. This article reviews the development of several novel targeted therapies that may be efficacious in the treatment of patients with breast cancer and highlights the challenges and opportunities associated with these agents.

UR - http://www.scopus.com/inward/record.url?scp=1542778660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542778660&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 1339

EP - 1351

JO - Oncology

JF - Oncology

SN - 0890-9091

IS - 10

ER -