The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.

Amir Fayyazuddin, Mahira A. Zaheer, P. Robin Hiesinger, Hugo J. Bellen

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Acetylcholine is the major excitatory neurotransmitter in the central nervous system of insects. Mutant analysis of the Dalpha7 nicotinic acetylcholine receptor (nAChR) of Drosophila shows that it is required for the giant fiber-mediated escape behavior. The Dalpha7 protein is enriched in the dendrites of the giant fiber, and electrophysiological analysis of the giant fiber circuit showed that sensory input to the giant fiber is disrupted, as is transmission at an identified cholinergic synapse between the peripherally synapsing interneuron and the dorsal lateral muscle motor neuron. Moreover, we found that gfA1, a mutation identified in a screen for giant fiber defects more than twenty years ago, is an allele of Dalpha7. Therefore, a combination of behavioral, electrophysiological, anatomical, and genetic data indicate an essential role for the Dalpha7 nAChR in giant fiber-mediated escape in Drosophila.

Original languageEnglish (US)
JournalPLoS Biology
Volume4
Issue number3
DOIs
StatePublished - Mar 2006

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escape behavior
cholinergic receptors
Nicotinic Receptors
Drosophila
Fibers
dendrites
cholinergic agents
interneurons
Motor Neurons
acetylcholine
Interneurons
synapse
motor neurons
Dendrites
neurotransmitters
Synapses
Cholinergic Agents
Acetylcholine
central nervous system
Neurotransmitter Agents

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. / Fayyazuddin, Amir; Zaheer, Mahira A.; Hiesinger, P. Robin; Bellen, Hugo J.

In: PLoS Biology, Vol. 4, No. 3, 03.2006.

Research output: Contribution to journalArticle

Fayyazuddin, Amir ; Zaheer, Mahira A. ; Hiesinger, P. Robin ; Bellen, Hugo J. / The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. In: PLoS Biology. 2006 ; Vol. 4, No. 3.
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