The Nlrp3 inflammasome: Contributions to intestinal homeostasis

Md Hasan Zaki, Mohamed Lamkanfi, Thirumala Devi Kanneganti

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute a major health problem in developed countries. Moreover, IBD predisposes to the development of colorectal cancer. The intracellular NOD-like receptor Nlrp3 is rapidly emerging as a crucial regulator of intestinal homeostasis. This innate immune receptor mediates assembly of the inflammasome complex in the presence of microbial ligands, triggering caspase-1 activation and secretion of IL-1β and IL-18. Recent studies suggest that defective Nlrp3 inflammasome signaling in the gut contributes to IBD through increased permeability across the epithelial barrier and the induction of detrimental immune responses against invading commensals. Here, we review and discuss recent advances of the role of the Nlrp3 inflammasome in colitis and colon tumorigenesis.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalTrends in Immunology
Volume32
Issue number4
DOIs
StatePublished - Apr 2011

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Inflammasomes
Inflammatory Bowel Diseases
Homeostasis
Caspase 1
Interleukin-18
Colitis
Interleukin-1
Ulcerative Colitis
Developed Countries
Crohn Disease
Colorectal Neoplasms
Permeability
Colon
Carcinogenesis
Ligands
Health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The Nlrp3 inflammasome : Contributions to intestinal homeostasis. / Zaki, Md Hasan; Lamkanfi, Mohamed; Kanneganti, Thirumala Devi.

In: Trends in Immunology, Vol. 32, No. 4, 04.2011, p. 171-179.

Research output: Contribution to journalArticle

Zaki, Md Hasan ; Lamkanfi, Mohamed ; Kanneganti, Thirumala Devi. / The Nlrp3 inflammasome : Contributions to intestinal homeostasis. In: Trends in Immunology. 2011 ; Vol. 32, No. 4. pp. 171-179.
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