The noncalciotropic actions of vitamin D

Recent clinical developments

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose of review This review summarizes recently described actions of 1,25-dihydroxyvitamin D beyond its function in calcium homeostasis and bone metabolism. Recent findings 1,25-Dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberculosis. Hypovitaminosis D has been associated with several autoimmune disorders, various malignancies, and cardiovascular risk factors in a number of recent epidemiologic reports. Based on these observational reports, vitamin D and its analogues are being evaluated for the prevention and treatment of a variety of conditions, with early findings showing mixed results. Summary The broad tissue distribution of the 25-hydroxyvitamin D 1a-hydroxylase enzyme and the vitamin D receptor establish a role for 1,25-dihydroxyvitamin D in the pathophysiology of various disease states and provide new therapeutic targets for vitamin D and its analogues.

Original languageEnglish (US)
Pages (from-to)408-415
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume17
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Vitamin D
Calcitriol Receptors
Tissue Distribution
Mixed Function Oxygenases
Immune System
Tuberculosis
Homeostasis
Calcium
Bone and Bones
Enzymes
Infection
1,25-dihydroxyvitamin D
Neoplasms
Therapeutics
25-hydroxyvitamin D

Keywords

  • 25-Hydroxyvitamin D 1α-hydroxylase
  • Vitamin D
  • Vitamin D receptor

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

The noncalciotropic actions of vitamin D : Recent clinical developments. / Maalouf, Naim M.

In: Current Opinion in Nephrology and Hypertension, Vol. 17, No. 4, 07.2008, p. 408-415.

Research output: Contribution to journalArticle

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