The Nonlipid Effects of Statins on Endothelial Function

Joshua A. Beckman, Mark A. Creager

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.

Original languageEnglish (US)
Pages (from-to)156-162
Number of pages7
JournalTrends in Cardiovascular Medicine
Issue number5
StatePublished - Jul 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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