TY - JOUR
T1 - The North Carolina-Louisiana Prostate Cancer Project (PCaP)
T2 - Methods and design of a multidisciplinary population-based cohort study of racial differences in prostate cancer outcomes
AU - Schroeder, Jane C.
AU - Bensen, Jeannette T.
AU - Su, L. Joseph
AU - Mishel, Merle
AU - Ivanova, Anastasia
AU - Smith, Gary J.
AU - Godley, Paul A.
AU - Fontham, Elizabeth T.H.
AU - Mohler, James L.
PY - 2006/8/1
Y1 - 2006/8/1
N2 - BACKGROUND. The North Carolina-Louisiana Prostate Cancer Project (PCaP) is a multi-disciplinary study of social, individual, and tumor-level causes of racial differences in prostate cancer aggressiveness. METHODS. A population-based sample of incident prostate cancer cases from North Carolina and Louisiana will include 1,000 African Americans and 1,000 Caucasian Americans. Study nurses administer structured questionnaires and collect blood, adipose tissue, urine, and toenail samples during an in-home visit. Clinical data are abstracted from medical records, diagnostic biopsies are reviewed and assayed, and tissue microarrays are constructed from prostatectomy samples. Prostate cancer aggressiveness is classified based on PSA, clinical stage, and Gleason grade. RESULTS. Preliminary data demonstrate between- and within-group differences in patient characteristics, screening, and treatment by race and state. Participation exceeds 70% in all groups. CONCLUSIONS. Preliminary data support the feasibility of this comprehensive study to help determine the focus of public health efforts to reduce racial disparities in prostate cancer mortality.
AB - BACKGROUND. The North Carolina-Louisiana Prostate Cancer Project (PCaP) is a multi-disciplinary study of social, individual, and tumor-level causes of racial differences in prostate cancer aggressiveness. METHODS. A population-based sample of incident prostate cancer cases from North Carolina and Louisiana will include 1,000 African Americans and 1,000 Caucasian Americans. Study nurses administer structured questionnaires and collect blood, adipose tissue, urine, and toenail samples during an in-home visit. Clinical data are abstracted from medical records, diagnostic biopsies are reviewed and assayed, and tissue microarrays are constructed from prostatectomy samples. Prostate cancer aggressiveness is classified based on PSA, clinical stage, and Gleason grade. RESULTS. Preliminary data demonstrate between- and within-group differences in patient characteristics, screening, and treatment by race and state. Participation exceeds 70% in all groups. CONCLUSIONS. Preliminary data support the feasibility of this comprehensive study to help determine the focus of public health efforts to reduce racial disparities in prostate cancer mortality.
KW - Diagnosis and screening
KW - Diet
KW - Epidemiology
KW - Genetic susceptibility
KW - Health care access and utilization
KW - Tumor biology
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U2 - 10.1002/pros.20449
DO - 10.1002/pros.20449
M3 - Review article
C2 - 16676364
AN - SCOPUS:33746820665
SN - 0270-4137
VL - 66
SP - 1162
EP - 1176
JO - Prostate
JF - Prostate
IS - 11
ER -