The Nuclear Envelope: An Intriguing Focal Point for Neurogenetic Disease

Howard J. Worman, William T. Dauer

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Mutations in genes encoding nuclear envelope proteins cause a wide range of inherited diseases, many of which are neurological. We review the genetic causes and what little is known about pathogenesis of these nuclear envelopathies that primarily affect striated muscle, peripheral nerve and the central nervous system. We conclude by providing examples of experimental therapeutic approaches to these rare but important neuromuscular diseases.

Original languageEnglish (US)
Pages (from-to)764-772
Number of pages9
JournalNeurotherapeutics
Volume11
Issue number4
DOIs
StatePublished - Oct 18 2014

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Keywords

  • Nuclear envelope
  • dystonia
  • lamin
  • leukodystrophy
  • muscular dystrophy

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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