The Nuclear Envelope as a Signaling Node in Development and Disease

William T. Dauer, Howard J. Worman

Research output: Contribution to journalReview article

149 Citations (Scopus)

Abstract

The development of a membrane-bound structure separating DNA from other cellular components was the epochal evolutionary event that gave rise to eukaryotes, possibly occurring up to 2 billion years ago. Yet, this view of the nuclear envelope as a physical barrier greatly underestimates its fundamental impact on cellular organization and complexity, much of which is only beginning to be understood. Indeed, alterations of nuclear envelope structure and protein composition are essential to many aspects of metazoan development and cellular differentiation. Mutations in genes encoding nuclear envelope proteins cause a fascinating array of diseases referred to as "nuclear envelopathies" or "laminopathies" that affect different tissues and organ systems. We review recent work on the nuclear envelope, including insights derived from the study of nuclear envelopathies. These studies are uncovering new functions for nuclear envelope proteins and underlie an emerging view of the nuclear envelope as a critical signaling node in development and disease.

Original languageEnglish (US)
Pages (from-to)626-638
Number of pages13
JournalDevelopmental Cell
Volume17
Issue number5
DOIs
StatePublished - Nov 17 2009
Externally publishedYes

Fingerprint

Nuclear Envelope
Nuclear Proteins
Proteins
Gene encoding
Tissue
Membranes
Architectural Accessibility
DNA
Eukaryota
Chemical analysis
Mutation
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

The Nuclear Envelope as a Signaling Node in Development and Disease. / Dauer, William T.; Worman, Howard J.

In: Developmental Cell, Vol. 17, No. 5, 17.11.2009, p. 626-638.

Research output: Contribution to journalReview article

@article{67ed780606fe46ec8453bc298601b564,
title = "The Nuclear Envelope as a Signaling Node in Development and Disease",
abstract = "The development of a membrane-bound structure separating DNA from other cellular components was the epochal evolutionary event that gave rise to eukaryotes, possibly occurring up to 2 billion years ago. Yet, this view of the nuclear envelope as a physical barrier greatly underestimates its fundamental impact on cellular organization and complexity, much of which is only beginning to be understood. Indeed, alterations of nuclear envelope structure and protein composition are essential to many aspects of metazoan development and cellular differentiation. Mutations in genes encoding nuclear envelope proteins cause a fascinating array of diseases referred to as {"}nuclear envelopathies{"} or {"}laminopathies{"} that affect different tissues and organ systems. We review recent work on the nuclear envelope, including insights derived from the study of nuclear envelopathies. These studies are uncovering new functions for nuclear envelope proteins and underlie an emerging view of the nuclear envelope as a critical signaling node in development and disease.",
author = "Dauer, {William T.} and Worman, {Howard J.}",
year = "2009",
month = "11",
day = "17",
doi = "10.1016/j.devcel.2009.10.016",
language = "English (US)",
volume = "17",
pages = "626--638",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - The Nuclear Envelope as a Signaling Node in Development and Disease

AU - Dauer, William T.

AU - Worman, Howard J.

PY - 2009/11/17

Y1 - 2009/11/17

N2 - The development of a membrane-bound structure separating DNA from other cellular components was the epochal evolutionary event that gave rise to eukaryotes, possibly occurring up to 2 billion years ago. Yet, this view of the nuclear envelope as a physical barrier greatly underestimates its fundamental impact on cellular organization and complexity, much of which is only beginning to be understood. Indeed, alterations of nuclear envelope structure and protein composition are essential to many aspects of metazoan development and cellular differentiation. Mutations in genes encoding nuclear envelope proteins cause a fascinating array of diseases referred to as "nuclear envelopathies" or "laminopathies" that affect different tissues and organ systems. We review recent work on the nuclear envelope, including insights derived from the study of nuclear envelopathies. These studies are uncovering new functions for nuclear envelope proteins and underlie an emerging view of the nuclear envelope as a critical signaling node in development and disease.

AB - The development of a membrane-bound structure separating DNA from other cellular components was the epochal evolutionary event that gave rise to eukaryotes, possibly occurring up to 2 billion years ago. Yet, this view of the nuclear envelope as a physical barrier greatly underestimates its fundamental impact on cellular organization and complexity, much of which is only beginning to be understood. Indeed, alterations of nuclear envelope structure and protein composition are essential to many aspects of metazoan development and cellular differentiation. Mutations in genes encoding nuclear envelope proteins cause a fascinating array of diseases referred to as "nuclear envelopathies" or "laminopathies" that affect different tissues and organ systems. We review recent work on the nuclear envelope, including insights derived from the study of nuclear envelopathies. These studies are uncovering new functions for nuclear envelope proteins and underlie an emerging view of the nuclear envelope as a critical signaling node in development and disease.

UR - http://www.scopus.com/inward/record.url?scp=71549117899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71549117899&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2009.10.016

DO - 10.1016/j.devcel.2009.10.016

M3 - Review article

C2 - 19922868

AN - SCOPUS:71549117899

VL - 17

SP - 626

EP - 638

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 5

ER -