The nuclear receptor PPARγ - Bigger than fat

Steven A. Kliewer, Timothy M. Willson

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


Work reported over the past year has provided insights into the mechanisms whereby ligand activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) regulates systemic glucose and lipid homeostasis. PPARγ has also been implicated recently in the biology of monocytes and in cell-cycle regulation and cancer. Polyunsaturated fatty acids and eicosanoids bind and activate PPARγ, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes.

Original languageEnglish (US)
Pages (from-to)576-581
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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