The occurrence of lactyl lactate and succinyl lactate in the urine of patients screened for inherited metabolic disease

D. Ketting, S. K. Wadman, L. Bruinvis, L. Sweetman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The gas Chromatographic and mass spectrometric identification of lactyl lactate and succinyl lactate, both present in human urine, is described. In the gas chromatogram lactyl lactate (as TMS derivative) presented as two peaks: the l,L- and/or d,d-form as well as the d, l- and/or the l,d-enantiomer. Both l- and d-lactyl succinate were excreted simultaneously. Lactyl lactate was observed in many patients; succinyl lactate only a few times and only together with lactyl lactate. No correlation with (endogenous) urinary lactate could be established. Presumably these compounds are products of the intestinal bacteria.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalClinica Chimica Acta
Volume146
Issue number1
DOIs
StatePublished - Feb 28 1985
Externally publishedYes

Keywords

  • Bacterial metabolites
  • Enantiomers
  • Lactyl lactate
  • Succinate lactate

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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