The opposed influences of β-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

D. Hilgemann, R. Englert, H. J. Mensing

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong β-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with a new method for recording continuous frequency-force loops are presented.

Original languageEnglish (US)
Pages (from-to)1629-1631
Number of pages3
JournalExperientia
Volume33
Issue number12
DOIs
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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