The origin of androgen and estrogen in a virilized postmenopausal woman with bilateral benign cystic teratomas

J. Aiman, R. H. Nalick, A. Jacobs, J. C. Porter, C. D. Edman, F. Vellios, P. C. MacDonald

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Abstract

Clitoromegaly was observed in a 73-year-old woman who had bilateral ovarian benign cystic teratomas that contained only epithelial derivatives. Scattered in the stroma of these ovaries were clusters of hyperplastic cells. The plasma testosterone production rate was 2.4 mg/day, a value that is ten times greater than that of normal postmenopausal women. The elevated plasma concentrations of testosterone and androstenedione decreased to normal by the second day after bilateral oophorectomy. Ovarian venous concentrations of testosterone and androstenedione were also increased and were considerably greater than those in peripheral blood. Estrone production was 68 μg/day, most of which could be accounted for by the extra-glandular formation from androstenedione. Estradiol production was 71μg/day, of which 75% was computed to arise from extraglandular formation and the remainder likely arose by ovarian secretion. The model increase in estrogen production was associated with slight cystic hyperplasia of the endometrium. From this study it is concluded that the hyperplastic ovarian stroma was the source of the excessive androgen production.

Original languageEnglish (US)
Pages (from-to)695-704
Number of pages10
JournalObstetrics and Gynecology
Volume49
Issue number6
Publication statusPublished - 1977

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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Aiman, J., Nalick, R. H., Jacobs, A., Porter, J. C., Edman, C. D., Vellios, F., & MacDonald, P. C. (1977). The origin of androgen and estrogen in a virilized postmenopausal woman with bilateral benign cystic teratomas. Obstetrics and Gynecology, 49(6), 695-704.