The Palade symposium: Celebrating cell biology at its best

Sandra L. Schmid, Marilyn G. Farquhar

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A symposium was held at the University of California, San Diego, to honor the contributions of Nobel Laureate, George Palade, to cell biology. The speakers included Günter Blobel, on the structure and function of nuclear pore complexes; Peter Walter, on the unfolded protein response in health and disease; Randy Schekman, on human disease-linked mutations in the COPII machinery; Scott Emr, on the regulation of plasma membrane composition by selective endocytosis; Roger Kornberg, on the structure and function of the transcription machinery; Peter Novick, on the regulation of rab GTPases along the secretory pathway; Jim Spudich, on the mechanism of the enigmatic myosin VI motor; and Joe Goldstein, on the function of the Niemann-Pick C (NPC)-linked gene products, NPC1 and NPC2, in cholesterol transport. Their work showcased the multidisciplinary nature, diversity, and vitality of cell biology. In the words of George Palade, their talks also illustrated "how cell biology could be used to understand disease and how disease could be used to discover normal cell biology." An integrated understanding of the cellular machinery will be essential in tackling the plethora of questions and challenges posed by completion of the human genome and for understanding the molecular mechanisms underlying human disease.

Original languageEnglish (US)
Pages (from-to)2367-2370
Number of pages4
JournalMolecular biology of the cell
Volume21
Issue number14
DOIs
StatePublished - Jul 15 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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