The parathyroid hormone-related protein associated with malignancy is secreted by neuroendocrine tumors

L. J. Deftos, A. F. Gazdar, K. Ikeda, A. E. Broadus

Research output: Contribution to journalArticle

85 Scopus citations


We have demonstrated the production of the PTH-related protein (PTHrP) associated with hypercalcemia of malignancy by human neuroendocrine cell lines that also produce calcitonin gene products and chromogranin A. PTHrP was demonstrable in the cells by immunocytochemistry and immunoassay and Northern analysis of the cells revealed the presence of multiple mRNAs for PTHrP. The cell lines also secreted PTHrP in a regulated fashion, with the most potent secretogogue being phorbol. Thus, PTHrP is secreted by neuroendocrine cells and it may have neuroectodermal lineage. The coexpression of calcitonin gene products and chromogranin A, also neuroendocrine, with PTHRP may influence its secretion and ultimate biological effectsin vivo.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalMolecular Endocrinology
Issue number3
StatePublished - Mar 1989


ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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