The paraventricular thalamus controls a central amygdala fear circuit

Mario A. Penzo, Vincent Robert, Jason Tucciarone, Dimitri De Bundel, Minghui Wang, Linda Van Aelst, Martin Darvas, Luis F. Parada, Richard D. Palmiter, Miao He, Z. Josh Huang, Bo Li

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Appropriate responses to an imminent threat brace us for adversities. The ability to sense and predict threatening or stressful events is essential for such adaptive behaviour. In the mammalian brain, one putative stress sensor is the paraventricular nucleus of the thalamus (PVT), an area that is readily activated by both physical and psychological stressors. However, the role of the PVT in the establishment of adaptive behavioural responses remains unclear. Here we show in mice that the PVT regulates fear processing in the lateral division of the central amygdala (CeL), a structure that orchestrates fear learning and expression. Selective inactivation of CeL-projecting PVT neurons prevented fear conditioning, an effect that can be accounted for by an impairment in fear-conditioning-induced synaptic potentiation onto somatostatin-expressing (SOM +) CeL neurons, which has previously been shown to store fear memory. Consistently, we found that PVT neurons preferentially innervate SOM + neurons in the CeL, and stimulation of PVT afferents facilitated SOM + neuron activity and promoted intra-CeL inhibition, two processes that are critical for fear learning and expression. Notably, PVT modulation of SOM + CeL neurons was mediated by activation of the brain-derived neurotrophic factor (BDNF) receptor tropomysin-related kinase B (TrkB). As a result, selective deletion of either Bdnf in the PVT or Trkb in SOM + CeL neurons impaired fear conditioning, while infusion of BDNF into the CeL enhanced fear learning and elicited unconditioned fear responses. Our results demonstrate that the PVT-CeL pathway constitutes a novel circuit essential for both the establishment of fear memory and the expression of fear responses, and uncover mechanisms linking stress detection in PVT with the emergence of adaptive behaviour.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
JournalNature
Volume519
Issue number7544
DOIs
StatePublished - Mar 26 2015

Fingerprint

Midline Thalamic Nuclei
Thalamus
Fear
Neurons
Psychological Adaptation
Learning
Central Amygdaloid Nucleus
trkB Receptor
Braces
Aptitude
Brain-Derived Neurotrophic Factor
Somatostatin
Phosphotransferases

ASJC Scopus subject areas

  • General

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Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., ... Li, B. (2015). The paraventricular thalamus controls a central amygdala fear circuit. Nature, 519(7544), 455-459. https://doi.org/10.1038/nature13978

The paraventricular thalamus controls a central amygdala fear circuit. / Penzo, Mario A.; Robert, Vincent; Tucciarone, Jason; De Bundel, Dimitri; Wang, Minghui; Van Aelst, Linda; Darvas, Martin; Parada, Luis F.; Palmiter, Richard D.; He, Miao; Huang, Z. Josh; Li, Bo.

In: Nature, Vol. 519, No. 7544, 26.03.2015, p. 455-459.

Research output: Contribution to journalArticle

Penzo, MA, Robert, V, Tucciarone, J, De Bundel, D, Wang, M, Van Aelst, L, Darvas, M, Parada, LF, Palmiter, RD, He, M, Huang, ZJ & Li, B 2015, 'The paraventricular thalamus controls a central amygdala fear circuit', Nature, vol. 519, no. 7544, pp. 455-459. https://doi.org/10.1038/nature13978
Penzo MA, Robert V, Tucciarone J, De Bundel D, Wang M, Van Aelst L et al. The paraventricular thalamus controls a central amygdala fear circuit. Nature. 2015 Mar 26;519(7544):455-459. https://doi.org/10.1038/nature13978
Penzo, Mario A. ; Robert, Vincent ; Tucciarone, Jason ; De Bundel, Dimitri ; Wang, Minghui ; Van Aelst, Linda ; Darvas, Martin ; Parada, Luis F. ; Palmiter, Richard D. ; He, Miao ; Huang, Z. Josh ; Li, Bo. / The paraventricular thalamus controls a central amygdala fear circuit. In: Nature. 2015 ; Vol. 519, No. 7544. pp. 455-459.
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