The Parkland Memorial Hospital protocol for treatment of eclampsia: Evaluation of 245 cases

Jack A. Pritchard, F. Gary Cunningham, Signe A. Pritchard

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

Since 1955, a standardized treatment regimen has been used to manage 245 cases of eclampsia at Parkland Memorial Hospital. Magnesium sulfate alone effectively controlled convulsions in the great majority of cases. The only maternal death among the 245 cases reemphasizes the risk of respiratory arrest that is inherent in the administration of magnesium sulfate when given in large doses intravenously. Hydralazine to lower the diastolic blood pressure somewhat, when it was 110 mm Hg or higher, prevented intracranial hemorrhage. Avoidance of diuretics and hyperosmotic agents and limitation of fluid intake were not associated with severe renal failure. Pulmonary edema was rare. Vaginal delivery was achieved in the majority of cases. Oxytocin often proved effective for initiating and maintaining labor even remote from term. The results obtained with this regimen justify its continued clinical application.

Original languageEnglish (US)
Pages (from-to)951-963
Number of pages13
JournalAmerican Journal of Obstetrics and Gynecology
Volume148
Issue number7
DOIs
StatePublished - Apr 1 1984

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Magnesium Sulfate
Eclampsia
Clinical Protocols
Blood Pressure
Hydralazine
Maternal Death
Intracranial Hemorrhages
Pulmonary Edema
Oxytocin
Diuretics
Renal Insufficiency
Seizures
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

The Parkland Memorial Hospital protocol for treatment of eclampsia : Evaluation of 245 cases. / Pritchard, Jack A.; Cunningham, F. Gary; Pritchard, Signe A.

In: American Journal of Obstetrics and Gynecology, Vol. 148, No. 7, 01.04.1984, p. 951-963.

Research output: Contribution to journalArticle

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