TY - JOUR
T1 - The PAT family of lipid droplet proteins in heart and vascular cells.
AU - Paul, Antoni
AU - Chan, Lawrence
AU - Bickel, Perry E.
N1 - Funding Information:
Supported by National Institutes of Health grants HL-51586 (to Dr. Chan) and DK-068046 (to Dr. Bickel). Dr. Chan was supported in part by the Betty Rutherford Chair from the St. Luke’s Episcopal Hospital and Baylor College of Medicine. Dr. Paul was supported in part by a Scientist Development Grant from the American Heart Association, National Research Program, 0535118N. Dr. Bickel thanks Dr. Nathan Wolins and Lora Staloch for expert immunostaining of mouse cardiomyocytes and Ilya Treskov and Dr. Anthony Muslin for help isolating mouse cardiomyocytes.
PY - 2008/12
Y1 - 2008/12
N2 - Cytoplasmic lipid droplets (LDs) are organelles in which cells store neutral lipids for use as an energy source in times of need, but they also play important roles in the regulation of key metabolic processes. Although LDs are essential for normal cell function, excess accumulation of intracellular lipid is associated with several metabolic diseases, including obesity, type 2 diabetes, and atherosclerosis. The function of LDs is regulated by their associated proteins, including the members of the PAT family: perilipin, adipophilin/adipose differentiation-related protein, tail-interacting protein 47, S3-12, and OXPAT/myocardial LD protein/lipid-storage droplet protein 5. In this review we discuss the PAT proteins in two cardiovascular contexts: 1) in the atherosclerotic vessel wall, where LDs within macrophage foam cells store cholesteryl esters derived from modified lipoproteins, and 2) in the myocardium, where LDs store fatty acids, the major energy substrate for normal heart function, as triglyceride.
AB - Cytoplasmic lipid droplets (LDs) are organelles in which cells store neutral lipids for use as an energy source in times of need, but they also play important roles in the regulation of key metabolic processes. Although LDs are essential for normal cell function, excess accumulation of intracellular lipid is associated with several metabolic diseases, including obesity, type 2 diabetes, and atherosclerosis. The function of LDs is regulated by their associated proteins, including the members of the PAT family: perilipin, adipophilin/adipose differentiation-related protein, tail-interacting protein 47, S3-12, and OXPAT/myocardial LD protein/lipid-storage droplet protein 5. In this review we discuss the PAT proteins in two cardiovascular contexts: 1) in the atherosclerotic vessel wall, where LDs within macrophage foam cells store cholesteryl esters derived from modified lipoproteins, and 2) in the myocardium, where LDs store fatty acids, the major energy substrate for normal heart function, as triglyceride.
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U2 - 10.1007/s11906-008-0086-y
DO - 10.1007/s11906-008-0086-y
M3 - Review article
C2 - 18959832
AN - SCOPUS:58949101878
VL - 10
SP - 461
EP - 466
JO - Current Hypertension Reports
JF - Current Hypertension Reports
SN - 1522-6417
IS - 6
ER -