The Pathogenesis and Management of Hypertension in Diabetic Kidney Disease

Peter N. Van Buren; Robert D. Toto

doi:10.1016/j.mcna.2012.10.003

The Pathogenesis and Management of Hypertension in Diabetic Kidney Disease

Peter N. Van Buren, Robert D. Toto

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Hypertension is one of the hallmark features of diabetic kidney disease. It contributes to both the progression of kidney disease and the risk for cardiovascular events in these patients. Although lowering blood pressure is critical in managing diabetic kidney disease, the ability to achieve this goal is complicated by the complexity of blood pressure regulation in these patients related to both extracellular volume expansion and increased vasoconstriction. This review includes a discussion of our current understanding of the etiology of hypertension in patients with diabetic kidney disease and an update of the most current clinical trials investigating antihypertensive interventions.

Original language	English (US)
Pages (from-to)	31-51
Number of pages	21
Journal	Medical Clinics of North America
Volume	97
Issue number	1
DOIs	https://doi.org/10.1016/j.mcna.2012.10.003
State	Published - Jan 2013

Keywords

ACE inhibitor
Hyperkalemia
Hypertension
RAAS therapy
Vasoconstriction

ASJC Scopus subject areas

General Medicine

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10.1016/j.mcna.2012.10.003

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title = "The Pathogenesis and Management of Hypertension in Diabetic Kidney Disease",

abstract = "Hypertension is one of the hallmark features of diabetic kidney disease. It contributes to both the progression of kidney disease and the risk for cardiovascular events in these patients. Although lowering blood pressure is critical in managing diabetic kidney disease, the ability to achieve this goal is complicated by the complexity of blood pressure regulation in these patients related to both extracellular volume expansion and increased vasoconstriction. This review includes a discussion of our current understanding of the etiology of hypertension in patients with diabetic kidney disease and an update of the most current clinical trials investigating antihypertensive interventions.",

keywords = "ACE inhibitor, Hyperkalemia, Hypertension, RAAS therapy, Vasoconstriction",

author = "{Van Buren}, {Peter N.} and Toto, {Robert D.}",

note = "Funding Information: This work was supported by funding from the American Heart Association Fellow to Faculty Transition Award (PVB) and the UT Southwestern O{\textquoteright}Brien Center ( NIH P30DK079328 ). This work was also conducted with support from UT-STAR , NIH/NCATS Grant Number KL2RR024983 . The conduct is solely the responsibility of the authors and does not necessarily represent the official views of the UT-STAR, The University of Texas Southwestern Medical Center at Dallas and its affiliated academic and health care centers, the National Center for Advancing Translational Sciences, or the National Institutes of Health. ",

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N2 - Hypertension is one of the hallmark features of diabetic kidney disease. It contributes to both the progression of kidney disease and the risk for cardiovascular events in these patients. Although lowering blood pressure is critical in managing diabetic kidney disease, the ability to achieve this goal is complicated by the complexity of blood pressure regulation in these patients related to both extracellular volume expansion and increased vasoconstriction. This review includes a discussion of our current understanding of the etiology of hypertension in patients with diabetic kidney disease and an update of the most current clinical trials investigating antihypertensive interventions.

AB - Hypertension is one of the hallmark features of diabetic kidney disease. It contributes to both the progression of kidney disease and the risk for cardiovascular events in these patients. Although lowering blood pressure is critical in managing diabetic kidney disease, the ability to achieve this goal is complicated by the complexity of blood pressure regulation in these patients related to both extracellular volume expansion and increased vasoconstriction. This review includes a discussion of our current understanding of the etiology of hypertension in patients with diabetic kidney disease and an update of the most current clinical trials investigating antihypertensive interventions.

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KW - Hyperkalemia

KW - Hypertension

KW - RAAS therapy

KW - Vasoconstriction

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The Pathogenesis and Management of Hypertension in Diabetic Kidney Disease

Abstract

Keywords

ASJC Scopus subject areas

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