The pathogenesis of Acanthamoeba keratitis

Jerry Y Niederkorn; Hassan Alizadeh; Henry Leher; James P McCulley

doi:10.1016/S1286-4579(99)80047-1

The pathogenesis of Acanthamoeba keratitis

Jerry Y Niederkorn, Hassan Alizadeh, Henry Leher, James P McCulley

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

Original language	English (US)
Pages (from-to)	437-443
Number of pages	7
Journal	Microbes and Infection
Volume	1
Issue number	6
DOIs	https://doi.org/10.1016/S1286-4579(99)80047-1
State	Published - May 1999

Keywords

Amoeba
Cornea
Keratitis
Ocular
Pathogenesis

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/S1286-4579(99)80047-1

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title = "The pathogenesis of Acanthamoeba keratitis",

abstract = "Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.",

keywords = "Amoeba, Cornea, Keratitis, Ocular, Pathogenesis",

author = "Niederkorn, {Jerry Y} and Hassan Alizadeh and Henry Leher and McCulley, {James P}",

note = "Funding Information: This work was supported by NIH grant EY09756 and an unrestricted grant from Research to Prevent Blindness, New York, NY.",

year = "1999",

month = may,

doi = "10.1016/S1286-4579(99)80047-1",

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T1 - The pathogenesis of Acanthamoeba keratitis

AU - Niederkorn, Jerry Y

AU - Alizadeh, Hassan

AU - Leher, Henry

AU - McCulley, James P

N1 - Funding Information: This work was supported by NIH grant EY09756 and an unrestricted grant from Research to Prevent Blindness, New York, NY.

PY - 1999/5

Y1 - 1999/5

N2 - Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

AB - Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

KW - Amoeba

KW - Cornea

KW - Keratitis

KW - Ocular

KW - Pathogenesis

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ER -

The pathogenesis of Acanthamoeba keratitis

Abstract

Keywords

ASJC Scopus subject areas

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