The pathogenesis of benign prostatic hyperplasia

Jean D. Wilson

Research output: Contribution to journalArticle

296 Citations (Scopus)

Abstract

Development of prostatic hyperplasia is an almost universal feature of the aging man and dog, and in both species the process develops only in males with intact testes. As the result of studies of plasma hormone levels as a function of age, measurements of the concentration of androgen and of androgen receptor proteins within the prostate, and studies of the effects of the administration of various hormones on growth of the prostate in the castrated dog, it is possible to provide a working hypothesis as to the pathogenesis. Dihydrotestosterone accumulation within the gland serves as the hormonal mediator for the hyperplasia in both species; the accumulation probably occurs in part because of decreased catabolism of the molecule and in part because of enhanced intracellular binding of the molecule. The process is accelerated by estrogen, which enhances the level of the androgen receptor in the gland; increase in the androgen receptor allows for androgen-mediated growth even in the face of declining androgen production in advanced age. On theoretic grounds the therapeutic implications of this model are exciting; several potential medical treatments may be feasible that do not involve a chemical castration.

Original languageEnglish (US)
Pages (from-to)745-756
Number of pages12
JournalThe American journal of medicine
Volume68
Issue number5
DOIs
StatePublished - 1980

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Androgen Receptors
Prostatic Hyperplasia
Androgens
Prostate
Dogs
Dihydrotestosterone
Castration
Growth Hormone
Hyperplasia
Testis
Estrogens
Hormones
Therapeutics
Growth
Proteins

ASJC Scopus subject areas

  • Nursing(all)

Cite this

The pathogenesis of benign prostatic hyperplasia. / Wilson, Jean D.

In: The American journal of medicine, Vol. 68, No. 5, 1980, p. 745-756.

Research output: Contribution to journalArticle

Wilson, Jean D. / The pathogenesis of benign prostatic hyperplasia. In: The American journal of medicine. 1980 ; Vol. 68, No. 5. pp. 745-756.
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