TY - JOUR
T1 - The pathological upgrading after radical prostatectomy in low-risk prostate cancer patients who are eligible for active surveillance
T2 - How safe is it to depend on bioptic pathology?
AU - Verep, Samed
AU - Erdem, Selcuk
AU - Ozluk, Yasemin
AU - Kilicaslan, Isin
AU - Sanli, Oner
AU - Ozcan, Faruk
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019
Y1 - 2019
N2 - Background: Active surveillance (AS) is one of the treatment alternatives in low-risk prostate cancer (PCa). The pathological upgrading after radical prostatectomy (RP) were investigated in patients who were eligible for AS in the present study. Methods: Between August 2006 and July 2017, 627 patients underwent RP in our institution. One hundred and thirty-six patients who were eligible for AS at the time of RP were included in this study. The previously defined AS criteria Gleason 3 + 3=6 adenocarcinoma at maximum two biopsy cores, prostate-specific antigen (PSA) < 10 ng/mL and clinical T stage ≤ 2a were used in the study. The demographics, clinical, and histopathological outcomes were retrospectively compared between two groups, which were divided in accordance with the upgrading status at final pathology as Group 1 (n = 67, upgrading) and Group 2 (n = 69, nonupgrading). Results: Gleason upgrading (GU) was found in 67 (49.3%) patients, and 17 patients (12.5%) were upstaged to pT3a. The upgrading to Gleason 3 + 4 was reported in 38.7% of patients, however, 7.4%, and 3.7% of the patients were upgraded to Gleason 4 + 3, and Gleason 4 + 4, respectively. The 10.3% of the patients had extraprostatic involvement, and the rate (19.4% vs 1.4%, P =.002) was significantly higher in Group 1. PSA density (P =.001), tumor size (P <.001), tumor percentage (P <.001), apical involvement (P =.013), and perineural invasion (P <.001) in RP specimen were higher in Group 1. Multivariate analysis showed that perineural invasion (OR = 4.26; 95%CI: 1.76-10.33; P =.001) and pathologic T stage (OR = 5.45; 95%CI: 1.08-27.4; P =.04) were independently associated with GU. Conclusions: Since 12.5% of the patients upstaged to pT3a disease, and there is a possible risk of Gleason 4 pattern, upgrading of the tumor should carefully be kept in mind before offering AS to low-risk patients with PCa.
AB - Background: Active surveillance (AS) is one of the treatment alternatives in low-risk prostate cancer (PCa). The pathological upgrading after radical prostatectomy (RP) were investigated in patients who were eligible for AS in the present study. Methods: Between August 2006 and July 2017, 627 patients underwent RP in our institution. One hundred and thirty-six patients who were eligible for AS at the time of RP were included in this study. The previously defined AS criteria Gleason 3 + 3=6 adenocarcinoma at maximum two biopsy cores, prostate-specific antigen (PSA) < 10 ng/mL and clinical T stage ≤ 2a were used in the study. The demographics, clinical, and histopathological outcomes were retrospectively compared between two groups, which were divided in accordance with the upgrading status at final pathology as Group 1 (n = 67, upgrading) and Group 2 (n = 69, nonupgrading). Results: Gleason upgrading (GU) was found in 67 (49.3%) patients, and 17 patients (12.5%) were upstaged to pT3a. The upgrading to Gleason 3 + 4 was reported in 38.7% of patients, however, 7.4%, and 3.7% of the patients were upgraded to Gleason 4 + 3, and Gleason 4 + 4, respectively. The 10.3% of the patients had extraprostatic involvement, and the rate (19.4% vs 1.4%, P =.002) was significantly higher in Group 1. PSA density (P =.001), tumor size (P <.001), tumor percentage (P <.001), apical involvement (P =.013), and perineural invasion (P <.001) in RP specimen were higher in Group 1. Multivariate analysis showed that perineural invasion (OR = 4.26; 95%CI: 1.76-10.33; P =.001) and pathologic T stage (OR = 5.45; 95%CI: 1.08-27.4; P =.04) were independently associated with GU. Conclusions: Since 12.5% of the patients upstaged to pT3a disease, and there is a possible risk of Gleason 4 pattern, upgrading of the tumor should carefully be kept in mind before offering AS to low-risk patients with PCa.
KW - active surveillance
KW - gleason upgrading
KW - prostate cancer
KW - radical prostatectomy
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U2 - 10.1002/pros.23873
DO - 10.1002/pros.23873
M3 - Article
C2 - 31269285
AN - SCOPUS:85070994318
SN - 0270-4137
VL - 79
SP - 1523
EP - 1529
JO - Prostate
JF - Prostate
IS - 13
ER -