The peptidoglycan recognition proteins LCa and LCx

C. I. Chang, J. Deisenhofer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Infection of bacteria triggers innate immune defense reactions in Drosophila. So far, the only bacterial component known to be recognized by the insect innate immune system is peptidoglycan, one of the most abundant constituents of the bacterial cell wall. Insects use peptidoglycan recognition proteins to detect peptidoglycan and to activate innate immune responses. Such specialized peptidoglycan receptors appear to have evolved from phage enzymes that hydrolyze bacterial cell walls. They are able to bind specific peptidoglycan molecules with distinct chemical moieties and activate innate immune pathways by interacting with other signaling proteins. Recent X-ray crystallographic studies of the peptidoglycan recognition proteins LCa, and LCx bound to peptidoglycan have provided structural insights into recognition of peptidoglycan and activation of innate immunity in insects.

Original languageEnglish (US)
Pages (from-to)1395-1402
Number of pages8
JournalCellular and Molecular Life Sciences
Volume64
Issue number11
DOIs
StatePublished - Jun 2007

Fingerprint

Peptidoglycan
Insects
Innate Immunity
Cell Wall
Cells
Bacteriophages
Immune system
Drosophila
Immune System
Bacteria
Chemical activation
X-Rays
peptidoglycan recognition protein
X rays
Molecules
Enzymes
Infection
Proteins

Keywords

  • Insect innate immunity
  • Peptidoglycan
  • PGRP-LCa
  • PGRP-LCx

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

The peptidoglycan recognition proteins LCa and LCx. / Chang, C. I.; Deisenhofer, J.

In: Cellular and Molecular Life Sciences, Vol. 64, No. 11, 06.2007, p. 1395-1402.

Research output: Contribution to journalArticle

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