The percentage of CD31+ T cells decreases after open but not laparoscopic surgery

I. Kirman; V. Cekic; N. Poltaratskaia; Z. Asi; S. Conte; D. Feingold; K. A. Forde; E. H. Huang; R. L. Whelan

doi:10.1007/s00464-002-8942-3

The percentage of CD31⁺ T cells decreases after open but not laparoscopic surgery

I. Kirman, V. Cekic, N. Poltaratskaia, Z. Asi, S. Conte, D. Feingold, K. A. Forde, E. H. Huang, R. L. Whelan

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3⁺ CD31⁺ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31⁺ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3⁺ CD31⁺ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3⁺ CD31⁺ cells and the length of incision in OS patients. Conclusions: The percentage of CD3⁺ CD31⁺ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

Original language	English (US)
Pages (from-to)	754-757
Number of pages	4
Journal	Surgical Endoscopy and Other Interventional Techniques
Volume	17
Issue number	5
DOIs	https://doi.org/10.1007/s00464-002-8942-3
State	Published - May 1 2003
Externally published	Yes

Keywords

CD31
Immune function
Laparoscopy
T cells

ASJC Scopus subject areas

Surgery

Access to Document

10.1007/s00464-002-8942-3

Cite this

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title = "The percentage of CD31+ T cells decreases after open but not laparoscopic surgery",

abstract = "Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.",

keywords = "CD31, Immune function, Laparoscopy, T cells",

author = "I. Kirman and V. Cekic and N. Poltaratskaia and Z. Asi and S. Conte and D. Feingold and Forde, {K. A.} and Huang, {E. H.} and Whelan, {R. L.}",

year = "2003",

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T1 - The percentage of CD31+ T cells decreases after open but not laparoscopic surgery

AU - Kirman, I.

AU - Cekic, V.

AU - Poltaratskaia, N.

AU - Asi, Z.

AU - Conte, S.

AU - Feingold, D.

AU - Forde, K. A.

AU - Huang, E. H.

AU - Whelan, R. L.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

AB - Background: Efficient killing of tumor cells depends on T cells that migrate from the circulation to the peripheral tissues; these cells express CD31. This study was undertaken to determine the impact of open (OS) and laparoscopic (LS) colorectal surgery on the percentage of circulating CD3+ CD31+ cells. Methods: Peripheral blood was collected from 27 OS and 24 LS colon cancer patients preoperatively (preOP) and on postoperative days 1 (POD1) and 3 (POD3). CD31+ T cells were assessed by flow cytometry using monoclonal antibodies. Results: In the OS group, the percentage of CD3+ CD31+ cells was significantly lower in POD1 and POD3 samples compared to the preOP results. LS surgery did not result in a significant change in the percentage of these T cells. A significant correlation was found between the decrease in the percentage of CD3+ CD31+ cells and the length of incision in OS patients. Conclusions: The percentage of CD3+ CD31+ cells decreases following OS but not LS and may be related to incision length. This may compromise T cell function in the peripheral tissues in the postoperative period.

KW - CD31

KW - Immune function

KW - Laparoscopy

KW - T cells

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