TY - JOUR
T1 - The pharmacology of intracellular Ca2+-release channels
AU - Ehrlich, Barbara E.
AU - Kaftan, Ed
AU - Bezprozvannaya, Svetlana
AU - Bezprozvanny, Ilya
PY - 1994/5
Y1 - 1994/5
N2 - Two classes of intracellular Ca2+-release channels, the ryanodine reccptor and the mositol (1,4,5)-trisphosphate (IP3) receptor, are essential for spatiotemporal Ca2+ signalling in cells. Heparin and caffeine have been widely used to study these channels. It was originally thought that caffeine acts solely as an agonist for the ryanodine receptoi and heparin acts solely as an inhibitor for the IP3 receptor. However, recent experiments indicate that these compounds have multiple effects, and are discussed in this review by Barbara Ehrlich and colleagues. In the same concentration range, caffeine activates the ryanodine receptor and inhibits the IP3 receptor, and hepaun inhibits the IP3 receptor and activates the ryanodine leceptor. More specific pharmacological tools that are suitable for studies of ryanodine and IP3 receptors are now beginning to emerge.
AB - Two classes of intracellular Ca2+-release channels, the ryanodine reccptor and the mositol (1,4,5)-trisphosphate (IP3) receptor, are essential for spatiotemporal Ca2+ signalling in cells. Heparin and caffeine have been widely used to study these channels. It was originally thought that caffeine acts solely as an agonist for the ryanodine receptoi and heparin acts solely as an inhibitor for the IP3 receptor. However, recent experiments indicate that these compounds have multiple effects, and are discussed in this review by Barbara Ehrlich and colleagues. In the same concentration range, caffeine activates the ryanodine receptor and inhibits the IP3 receptor, and hepaun inhibits the IP3 receptor and activates the ryanodine leceptor. More specific pharmacological tools that are suitable for studies of ryanodine and IP3 receptors are now beginning to emerge.
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U2 - 10.1016/0165-6147(94)90074-4
DO - 10.1016/0165-6147(94)90074-4
M3 - Article
C2 - 7754532
AN - SCOPUS:0028176196
SN - 0165-6147
VL - 15
SP - 145
EP - 149
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 5
ER -