TY - JOUR
T1 - The PI3K pathway as drug target in human cancer
AU - Courtney, Kevin D.
AU - Corcoran, Ryan B.
AU - Engelman, Jeffrey A.
PY - 2010/2/20
Y1 - 2010/2/20
N2 - The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth, survival, motility, and metabolism. This pathway is activated by several different mechanisms in cancers, including somatic mutation and amplification of genes encoding key components. In addition, PI3K signaling may serve integral functions for noncancerous cells in the tumor microenvironment. Consequently, therapeutics targeting the PI3K pathway are being developed at a rapid pace, and preclinical and early clinical studies are beginning to suggest specific strategies to effectively use them. However, the central role of PI3K signaling in a large array of diverse biologic processes raises concerns about its use in therapeutics and increases the need to develop sophisticated strategies for its use. In this review, we will discuss how PI3K signaling affects the growth and survival of tumor cells. From this vantage, we will consider how inhibitors of the PI3K signaling cascade, either alone or in combination with other therapeutics, can most effectively be used for the treatment of cancer.
AB - The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth, survival, motility, and metabolism. This pathway is activated by several different mechanisms in cancers, including somatic mutation and amplification of genes encoding key components. In addition, PI3K signaling may serve integral functions for noncancerous cells in the tumor microenvironment. Consequently, therapeutics targeting the PI3K pathway are being developed at a rapid pace, and preclinical and early clinical studies are beginning to suggest specific strategies to effectively use them. However, the central role of PI3K signaling in a large array of diverse biologic processes raises concerns about its use in therapeutics and increases the need to develop sophisticated strategies for its use. In this review, we will discuss how PI3K signaling affects the growth and survival of tumor cells. From this vantage, we will consider how inhibitors of the PI3K signaling cascade, either alone or in combination with other therapeutics, can most effectively be used for the treatment of cancer.
UR - http://www.scopus.com/inward/record.url?scp=77949881462&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949881462&partnerID=8YFLogxK
U2 - 10.1200/JCO.2009.25.3641
DO - 10.1200/JCO.2009.25.3641
M3 - Review article
C2 - 20085938
AN - SCOPUS:77949881462
SN - 0732-183X
VL - 28
SP - 1075
EP - 1083
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 6
ER -