The pivotal role of pathology in the management of lung cancer

Morgan R. Davidson, Adi F. Gazdar, Belinda E. Clarke

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The last decade has seen significant advances in our understanding of lung cancer biology and management. Identification of key driver events in lung carcinogenesis has contributed to the development of targeted lung cancer therapies, heralding the era of personalised medicine for lung cancer. As a result, histological subtyping and molecular testing has become of paramount importance, placing increasing demands on often small diagnostic specimens. This has triggered the review and development of the first structured classification of lung cancer in small biopsy/cytology specimens and a new classification of lung adenocarcinoma from the IASLC/ATS/ERS. These have enhanced the clinical relevance of pathological diagnosis, and emphasise the role of the modern surgical pathologist as an integral member of the multidisciplinary team, playing a crucial role in clinical trials and determining appropriate and timely management for patients with lung cancer.

Original languageEnglish (US)
JournalJournal of Thoracic Disease
Volume5
Issue numberSUPPL.5
DOIs
StatePublished - 2013

Fingerprint

Lung Neoplasms
Pathology
Precision Medicine
Cell Biology
Carcinogenesis
Clinical Trials
Biopsy
Lung
Therapeutics

Keywords

  • Lung neoplasms
  • Non-small-cell lung carcinoma (NSCLC)
  • Pathology
  • small cell lung carcinoma (SCLC)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The pivotal role of pathology in the management of lung cancer. / Davidson, Morgan R.; Gazdar, Adi F.; Clarke, Belinda E.

In: Journal of Thoracic Disease, Vol. 5, No. SUPPL.5, 2013.

Research output: Contribution to journalArticle

Davidson, Morgan R. ; Gazdar, Adi F. ; Clarke, Belinda E. / The pivotal role of pathology in the management of lung cancer. In: Journal of Thoracic Disease. 2013 ; Vol. 5, No. SUPPL.5.
@article{c87c4f6965ef4e1ba323a88792fb7d3a,
title = "The pivotal role of pathology in the management of lung cancer",
abstract = "The last decade has seen significant advances in our understanding of lung cancer biology and management. Identification of key driver events in lung carcinogenesis has contributed to the development of targeted lung cancer therapies, heralding the era of personalised medicine for lung cancer. As a result, histological subtyping and molecular testing has become of paramount importance, placing increasing demands on often small diagnostic specimens. This has triggered the review and development of the first structured classification of lung cancer in small biopsy/cytology specimens and a new classification of lung adenocarcinoma from the IASLC/ATS/ERS. These have enhanced the clinical relevance of pathological diagnosis, and emphasise the role of the modern surgical pathologist as an integral member of the multidisciplinary team, playing a crucial role in clinical trials and determining appropriate and timely management for patients with lung cancer.",
keywords = "Lung neoplasms, Non-small-cell lung carcinoma (NSCLC), Pathology, small cell lung carcinoma (SCLC)",
author = "Davidson, {Morgan R.} and Gazdar, {Adi F.} and Clarke, {Belinda E.}",
year = "2013",
doi = "10.3978/j.issn.2072-1439.2013.08.43",
language = "English (US)",
volume = "5",
journal = "Journal of Thoracic Disease",
issn = "2072-1439",
publisher = "Pioneer Bioscience Publishing Company (PBPC)",
number = "SUPPL.5",

}

TY - JOUR

T1 - The pivotal role of pathology in the management of lung cancer

AU - Davidson, Morgan R.

AU - Gazdar, Adi F.

AU - Clarke, Belinda E.

PY - 2013

Y1 - 2013

N2 - The last decade has seen significant advances in our understanding of lung cancer biology and management. Identification of key driver events in lung carcinogenesis has contributed to the development of targeted lung cancer therapies, heralding the era of personalised medicine for lung cancer. As a result, histological subtyping and molecular testing has become of paramount importance, placing increasing demands on often small diagnostic specimens. This has triggered the review and development of the first structured classification of lung cancer in small biopsy/cytology specimens and a new classification of lung adenocarcinoma from the IASLC/ATS/ERS. These have enhanced the clinical relevance of pathological diagnosis, and emphasise the role of the modern surgical pathologist as an integral member of the multidisciplinary team, playing a crucial role in clinical trials and determining appropriate and timely management for patients with lung cancer.

AB - The last decade has seen significant advances in our understanding of lung cancer biology and management. Identification of key driver events in lung carcinogenesis has contributed to the development of targeted lung cancer therapies, heralding the era of personalised medicine for lung cancer. As a result, histological subtyping and molecular testing has become of paramount importance, placing increasing demands on often small diagnostic specimens. This has triggered the review and development of the first structured classification of lung cancer in small biopsy/cytology specimens and a new classification of lung adenocarcinoma from the IASLC/ATS/ERS. These have enhanced the clinical relevance of pathological diagnosis, and emphasise the role of the modern surgical pathologist as an integral member of the multidisciplinary team, playing a crucial role in clinical trials and determining appropriate and timely management for patients with lung cancer.

KW - Lung neoplasms

KW - Non-small-cell lung carcinoma (NSCLC)

KW - Pathology

KW - small cell lung carcinoma (SCLC)

UR - http://www.scopus.com/inward/record.url?scp=84898736387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898736387&partnerID=8YFLogxK

U2 - 10.3978/j.issn.2072-1439.2013.08.43

DO - 10.3978/j.issn.2072-1439.2013.08.43

M3 - Article

C2 - 24163740

AN - SCOPUS:84898736387

VL - 5

JO - Journal of Thoracic Disease

JF - Journal of Thoracic Disease

SN - 2072-1439

IS - SUPPL.5

ER -