The place of diuretics in preventing cardiovascular events

Norman M Kaplan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Low-dose diuretics are recommended for the initial choice of antihypertensive therapy in the 7th US Joint National Committee report and are accepted as an appropriate choice among other classes of drugs in the 2003 European Society of Hypertension guidelines. The rationales for the use of low-dose diuretics include the following: • Renal dysfunction interfering with normal natriuresis is likely a fundamental defect in the pathogenesis of hypertension. • Subtle renal insufficiency that interferes with sodium excretion is a common consequence of uncontrolled hypertension. • Diuretic-based therapy has been clearly documented in placebo-controlled, randomized trials to reduce cardiovascular morbidity and mortality, particularly in the treatment of elderly hypertensives. • In multiple comparative trials, diuretic-based therapy has been shown to provide equal cardiovascular protection to that provided by newer agents. • Diuretics enhance the antihypertensive efficacy of all other classes of agents. • As lower blood pressure goals of therapy have been found to be needed, diuretic enhancement of other agents' efficacy has become even more essential. With such low doses, side effects are minimal in degree and infrequent in appearance.

Original languageEnglish (US)
JournalJournal of Human Hypertension
Volume18
Issue numberSUPPL. 2
DOIs
StatePublished - Dec 2004

Fingerprint

Diuretics
Antihypertensive Agents
Hypertension
Therapeutics
Civil Rights
Natriuresis
Renal Insufficiency
Randomized Controlled Trials
Sodium
Placebos
Guidelines
Blood Pressure
Morbidity
Kidney
Mortality
Pharmaceutical Preparations

Keywords

  • Cardiovascular protection
  • Diuretics
  • Low-dose therapy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The place of diuretics in preventing cardiovascular events. / Kaplan, Norman M.

In: Journal of Human Hypertension, Vol. 18, No. SUPPL. 2, 12.2004.

Research output: Contribution to journalArticle

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