The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent

Kyle J. Miller, Ali A. Saherwala, Benjamin C. Webber, Yunkou Wu, A. Dean Sherry, Mark Woods

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.

Original languageEnglish (US)
Pages (from-to)8662-8664
Number of pages3
JournalInorganic Chemistry
Volume49
Issue number19
DOIs
StatePublished - Oct 4 2010

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Lanthanoid Series Elements
chelates
Amides
Isomers
Magnetic resonance imaging
Contrast Media
isomers
Kinetics
Water
amides
kinetics
water
cyclen

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry

Cite this

The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent. / Miller, Kyle J.; Saherwala, Ali A.; Webber, Benjamin C.; Wu, Yunkou; Sherry, A. Dean; Woods, Mark.

In: Inorganic Chemistry, Vol. 49, No. 19, 04.10.2010, p. 8662-8664.

Research output: Contribution to journalArticle

Miller, Kyle J. ; Saherwala, Ali A. ; Webber, Benjamin C. ; Wu, Yunkou ; Sherry, A. Dean ; Woods, Mark. / The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent. In: Inorganic Chemistry. 2010 ; Vol. 49, No. 19. pp. 8662-8664.
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