The pore-forming bacterial effector, VopQ, halts autophagic turnover

Anju Sreelatha, Kim Orth, Vincent J. Starai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Vibrio parahemolyticus Type III effector VopQ is both necessary and sufficient to induce autophagy within one hour of infection. We demonstrated that VopQ interacts with the Vo domain of the conserved vacuolar H+ -ATPase. Membrane-associated VopQ subsequently forms pores in the membranes of acidic compartments, resulting in immediate release of protons without concomitant release of lumenal protein contents. These studies show how a bacterial pathogen can compromise host ion potentials using a gated pore-forming effector to equilibrate levels of small molecules found in endolysosomal compartments and disrupt cellular processes such as autophagy.

Original languageEnglish (US)
Pages (from-to)2169-2170
Number of pages2
JournalAutophagy
Volume9
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

Autophagy
Vacuolar Proton-Translocating ATPases
Vibrio parahaemolyticus
Membranes
Protons
Ions
Infection
Proteins

Keywords

  • Autophagy
  • Channel
  • Pore
  • T3SS
  • Vibrio
  • Virulence factor
  • VopQ

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

The pore-forming bacterial effector, VopQ, halts autophagic turnover. / Sreelatha, Anju; Orth, Kim; Starai, Vincent J.

In: Autophagy, Vol. 9, No. 12, 12.2013, p. 2169-2170.

Research output: Contribution to journalArticle

Sreelatha, Anju ; Orth, Kim ; Starai, Vincent J. / The pore-forming bacterial effector, VopQ, halts autophagic turnover. In: Autophagy. 2013 ; Vol. 9, No. 12. pp. 2169-2170.
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