The pore-forming bacterial effector, VopQ, halts autophagic turnover

Anju Sreelatha, Kim Orth, Vincent J. Starai

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Vibrio parahemolyticus Type III effector VopQ is both necessary and sufficient to induce autophagy within one hour of infection. We demonstrated that VopQ interacts with the Vo domain of the conserved vacuolar H+ -ATPase. Membrane-associated VopQ subsequently forms pores in the membranes of acidic compartments, resulting in immediate release of protons without concomitant release of lumenal protein contents. These studies show how a bacterial pathogen can compromise host ion potentials using a gated pore-forming effector to equilibrate levels of small molecules found in endolysosomal compartments and disrupt cellular processes such as autophagy.

Original languageEnglish (US)
Pages (from-to)2169-2170
Number of pages2
JournalAutophagy
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2013

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Keywords

  • Autophagy
  • Channel
  • Pore
  • T3SS
  • Vibrio
  • Virulence factor
  • VopQ

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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