The possible role of endothelin-1 in the pathogenesis of coronary vasospasm

H. Kurihara, M. Yoshizumi, T. Sugiyama, K. Yamaoki, R. Nagai, F. Takaku, H. Satoh, J. Inui, M. Yanagisawa, T. Masaki, Y. Yazaki

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Abstract

We investigated the in vivo vasoconstrictor effects of endothelin-1 (ET-1) on canine coronary arteries and the regulation of ET-1 gene expression with special reference to the pathogenesis of coronary vasospasm. ET-1, administered into the coronary arteries of anesthetized dogs, produced a profound and long-lasting reduction in coronary blood flow with myocardial ischemia. Coronary angiography revealed delayed filling of the distal branches and, in some cases, total occlusion in the epicardial portions of coronary arteries. The coronary vasoconstriction induced by ET-1 subsided after intracoronary administration of nitroglycerin. Pretreatment with the Ca2+-channel antagonist, nitrendipine, suppressed ET-1-induced vasoconstriction. In cultured porcine aortic endothelial cells, ET-1 gene expression was induced by agents related to thrombus formation, such as thrombin and transforming growth factor β (TGFβ). These findings suggest that ET-1, produced by vascular endothelial cells, may contribute to the regulation of coronary circulation and the pathogenesis of coronary vasospasm with respect to intimal injury and subsequent thrombus formation.

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Volume13
Issue numberSUPPL. 5
StatePublished - 1989

Fingerprint

Coronary Vasospasm
Endothelin-1
Coronary Vessels
Vasoconstriction
Thrombosis
Endothelial Cells
Tunica Intima
Nitrendipine
Gene Expression
Coronary Circulation
Nitroglycerin
Transforming Growth Factors
Vasoconstrictor Agents
Coronary Angiography
Thrombin
Myocardial Ischemia
Canidae
Swine
Dogs
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Kurihara, H., Yoshizumi, M., Sugiyama, T., Yamaoki, K., Nagai, R., Takaku, F., ... Yazaki, Y. (1989). The possible role of endothelin-1 in the pathogenesis of coronary vasospasm. Journal of Cardiovascular Pharmacology, 13(SUPPL. 5).

The possible role of endothelin-1 in the pathogenesis of coronary vasospasm. / Kurihara, H.; Yoshizumi, M.; Sugiyama, T.; Yamaoki, K.; Nagai, R.; Takaku, F.; Satoh, H.; Inui, J.; Yanagisawa, M.; Masaki, T.; Yazaki, Y.

In: Journal of Cardiovascular Pharmacology, Vol. 13, No. SUPPL. 5, 1989.

Research output: Contribution to journalArticle

Kurihara, H, Yoshizumi, M, Sugiyama, T, Yamaoki, K, Nagai, R, Takaku, F, Satoh, H, Inui, J, Yanagisawa, M, Masaki, T & Yazaki, Y 1989, 'The possible role of endothelin-1 in the pathogenesis of coronary vasospasm', Journal of Cardiovascular Pharmacology, vol. 13, no. SUPPL. 5.
Kurihara H, Yoshizumi M, Sugiyama T, Yamaoki K, Nagai R, Takaku F et al. The possible role of endothelin-1 in the pathogenesis of coronary vasospasm. Journal of Cardiovascular Pharmacology. 1989;13(SUPPL. 5).
Kurihara, H. ; Yoshizumi, M. ; Sugiyama, T. ; Yamaoki, K. ; Nagai, R. ; Takaku, F. ; Satoh, H. ; Inui, J. ; Yanagisawa, M. ; Masaki, T. ; Yazaki, Y. / The possible role of endothelin-1 in the pathogenesis of coronary vasospasm. In: Journal of Cardiovascular Pharmacology. 1989 ; Vol. 13, No. SUPPL. 5.
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