The possible role of the arterial microcirculation in the pathogenesis of atherosclerosis

Elliott Groszek, Scott M Grundy

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Figure 3 outlines the microvascular hypothesis of atherosclerosis. We propose that the arterial microcirculation contributes to atherosclerosis through at least three mechanisms. First, injury to arterioles or arteriolar capillaries might cause increased passage of lipoproteins into subintimal tissue (Fig. 3A). This process could continue even when a large fibrous cap prevents transintimal filtration. Second, in areas where vasa vasorum (primary vascularization) are sparse or lacking, removal of lipids and lipoproteins could be retarded enhancing their accumulation (Fig. 3B). Third, defective secondary vascularization of existing plaques could be an additional source of lipoproteins for accumulation of lipids in the arterial wall (Fig. 3C). Thus, we propose that investigators should take a fresh look into the role of the microcirculation as a factor in the pathogenesis of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)679-684
Number of pages6
JournalJournal of Chronic Diseases
Volume33
Issue number11-12
DOIs
StatePublished - 1980

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Microcirculation
Lipoproteins
Atherosclerosis
Vasa Vasorum
Lipids
Arterioles
Research Personnel
Wounds and Injuries

ASJC Scopus subject areas

  • Epidemiology

Cite this

The possible role of the arterial microcirculation in the pathogenesis of atherosclerosis. / Groszek, Elliott; Grundy, Scott M.

In: Journal of Chronic Diseases, Vol. 33, No. 11-12, 1980, p. 679-684.

Research output: Contribution to journalArticle

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