The potential role of gene therapy in the treatment of bladder cancer

Jer Tsong Hsieh, Colin P N Dinney, Leland W K Chung

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Based on understanding the molecular mechanism of bladder carcinogenesis, cancer gene therapy may well become a novel therapy in the near future. Currently, a viral vector system appears to be a better vehicle to deliver genes into target cells. Exploring different therapeutic strategies has generated promising results from preclinical bladder cancer models. Phase I clinical trials are underway to study the feasibility of this treatment for human bladder cancer patients. However, several potential problems associated with effective gene delivery need to be further refined.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalUrologic Clinics of North America
Volume27
Issue number1
StatePublished - 2000

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Urinary Bladder Neoplasms
Genetic Therapy
Clinical Trials, Phase I
Neoplasm Genes
Feasibility Studies
Genes
Carcinogenesis
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

The potential role of gene therapy in the treatment of bladder cancer. / Hsieh, Jer Tsong; Dinney, Colin P N; Chung, Leland W K.

In: Urologic Clinics of North America, Vol. 27, No. 1, 2000, p. 103-113.

Research output: Contribution to journalArticle

Hsieh, Jer Tsong ; Dinney, Colin P N ; Chung, Leland W K. / The potential role of gene therapy in the treatment of bladder cancer. In: Urologic Clinics of North America. 2000 ; Vol. 27, No. 1. pp. 103-113.
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