The potential role of gene therapy in the treatment of bladder cancer

Jer Tsong Hsieh; Colin P N Dinney; Leland W K Chung

doi:10.1016/S0094-0143(05)70238-X

The potential role of gene therapy in the treatment of bladder cancer

Jer Tsong Hsieh, Colin P N Dinney, Leland W K Chung

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Based on understanding the molecular mechanism of bladder carcinogenesis, cancer gene therapy may well become a novel therapy in the near future. Currently, a viral vector system appears to be a better vehicle to deliver genes into target cells. Exploring different therapeutic strategies has generated promising results from preclinical bladder cancer models. Phase I clinical trials are underway to study the feasibility of this treatment for human bladder cancer patients. However, several potential problems associated with effective gene delivery need to be further refined.

Original language	English (US)
Pages (from-to)	103-113
Number of pages	11
Journal	Urologic Clinics of North America
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/S0094-0143(05)70238-X
State	Published - 2000

ASJC Scopus subject areas

Urology

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10.1016/S0094-0143(05)70238-X

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abstract = "Based on understanding the molecular mechanism of bladder carcinogenesis, cancer gene therapy may well become a novel therapy in the near future. Currently, a viral vector system appears to be a better vehicle to deliver genes into target cells. Exploring different therapeutic strategies has generated promising results from preclinical bladder cancer models. Phase I clinical trials are underway to study the feasibility of this treatment for human bladder cancer patients. However, several potential problems associated with effective gene delivery need to be further refined.",

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The potential role of gene therapy in the treatment of bladder cancer

Abstract

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